There are disclosed novel 4-substituted amino-.alpha.-aminomethylbenzyl alcohol derivatives represented by the formula: ##STR1## wherein X represents a halogen atom; Y represents a hydrogen atom or a halogen atom; R.sub.1 represents a lower alkyl group, a carbamoyl group, a mono- or di-lower alkyl-substituted carbamoyl group, a phenyl-substituted carbamoyl group, a lower alkoxycarbonyl group, a lower alkoxy-substituted lower alkoxycarbonyl group, a phenyl-substituted lower alkoxycarbonyl group, or a cycloalkyloxycarbonyl group; and R.sub.2 represents a lower alkyl group, a cycloalkyl group, or the group shown by the ##STR2## wherein R.sub.3 represents a hydrogen atom or a lower alkyl group and R.sub.4 represents a hydrogen atom, a hydroxy group, or a lower alkoxy group and the pharmaceutically acceptable nontoxic salts thereof. These compounds are antiasthmatic agents useful for the prophylaxis and treatment of asthma.
公开了一种新型的4-取代
氨基-.alpha.-
氨甲基
苯甲醇衍
生物,其
化学式表示为:##STR1## 其中X代表卤素原子;Y代表氢原子或卤素原子;R.sub.1代表较低的烷基、
氨基甲酰基、单或双较低烷基取代的
氨基甲酰基、苯基取代的
氨基甲酰基、较低的烷氧羰基基、较低烷基取代的较低烷氧羰基基、苯基取代的较低烷氧羰基基或环烷氧羰基基;R.sub.2代表较低的烷基、环烷基或由##STR2##所示的基团;其中R.sub.3代表氢原子或较低的烷基,R.sub.4代表氢原子、羟基或较低的烷氧基,以及其药学上可接受的无毒盐。这些化合物是抗哮喘剂,对哮喘的预防和治疗有用。