tetra(2-aminoethyl)methane | 129880-56-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tetra(2-aminoethyl)methane
• 英文别名: 3,3-Bis(2-aminoethyl)pentane-1,5-diamine
• CAS: 129880-56-4
• 化学式: C₉H₂₄N₄
• 分子量: 188.316
• InChiKey: MFDFNHXWYABALH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-trimethylsilylethyl 2,4-dioxo-10-[4-[(E)-3-oxo-3-(2-trimethylsilylethoxy)prop-1-enyl]phenyl]-3-oxatricyclo[7.3.1.05,13]trideca-1(13),5,7,9,11-pentaene-8-carboxylate 、 tetra(2-aminoethyl)methane 在 zinc diacetate 作用下， 以 均三甲苯 为溶剂， 以34%的产率得到
  参考文献：
  名称：

  Heterocycles in Organic Materials Chemistry. Synthesis of Di-, Tri-, and Tetraimide Polycarboxylic Acids for Use in Organic Network Assembly

  摘要：

  DOI：

  10.3987/com-01-9242
• 作为产物：
  描述：

  1,5-二溴‐3,3-双(2-溴乙基)戊烷 在 palladium on activated charcoal sodium azide 、 氢气 作用下， 以 乙醇 、 二甲基亚砜 为溶剂， 20.0 ℃ 、275.79 kPa 条件下， 反应 27.5h， 生成 tetra(2-aminoethyl)methane
  参考文献：
  名称：

  Facile Preparation of Tetra(2-aminoethyl)methane and Tetra(3-aminopropyl)methane:  Novel Tetravalent Monomers for Materials Synthesis

  摘要：

  DOI：

  10.1021/jo9908391

文献信息

• TARGETED POLYLYSINE DENDRIMER THERAPEUTIC AGENT
  申请人：Krippner Guy Yeoman

  公开号：US20100292148A1

  公开（公告）日：2010-11-18

  The present invention relates generally to branched macromolecules bearing functional moieties. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties. The invention further relates to the use of such macromolecules, particularly in therapeutic applications, and compositions comprising them.

  本发明通常涉及带有功能基团的分支大分子。特别是，本发明涉及从赖氨酸或赖氨酸类似物中派生出的树状分子，其带有多个功能基团。本发明还涉及这种大分子的使用，特别是在治疗应用中，以及包含它们的组合物。
• Macromolecular Compounds Having Controlled Stoichiometry
  申请人：Krippner Guy Yeoman

  公开号：US20090118467A1

  公开（公告）日：2009-05-07

  The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.

  以下发明涉及具有可控化学计量和拓扑结构的高分子，其生产过程以及其使用的应用。这些高分子具有可控的功能基团化学计量，并包括至少一个树枝状基序，其表面层由至少一个表面构建单元形成，而至少一个次表面层由至少一个构建单元形成，表面构建单元和构建单元具有一个碳氢骨架，带有一个羰基基团和至少一个胺基团；以及构建单元和/或表面构建单元上至少两种不同的功能基团；其中功能基团化学计量指的是功能基团的数量和类型。
• POLYLYSINE DENDRIMER CONTRAST AGENT
  申请人：Krippner Guy Yeoman

  公开号：US20100278750A1

  公开（公告）日：2010-11-04

  The present invention relates generally to branched macromolecules and their use as imaging or contrast agents. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties and their application to imaging techniques in which a disease state may be imaged with a targeted contrast agent.

  本发明通常涉及分支大分子及其作为成像或对比剂的使用。具体而言，本发明涉及从赖氨酸或赖氨酸类似物派生的树状分子，带有多种功能基团，并将它们应用于成像技术中，其中可以使用定向对比剂成像疾病状态。
• MACROMOLECULAR COMPOUNDS HAVING CONTROLLED STOICHIOMETRY
  申请人：Krippner Guy Yeoman

  公开号：US20120302730A1

  公开（公告）日：2012-11-29

  The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.

  以下发明涉及具有控制的化学计量和拓扑结构的大分子，其生产过程以及其使用的应用。这些大分子具有受控的功能基团化学计量，并且包括至少一个树枝状基元，其表面层由至少一个表面构建单元形成，而至少一个亚表面层由至少一个构建单元形成，表面构建单元和构建单元具有带有羰基和至少一个胺基的碳氢骨架；以及在构建单元和/或表面构建单元上至少两种不同的功能基团；其中功能基团化学计量指的是功能基团的数量和类型。
• MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES
  申请人：STARPHARMA PTY LTD.

  公开号：US20160220689A1

  公开（公告）日：2016-08-04

  A macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached is provided. The macromolecule may have a plurality of platinum-containing moieties attached to the surface amino groups. Alternatively, the macromolecule may comprise a dendrimer having surface amino groups to which at least two different moieties are attached, a first moiety being a platinum-containing moiety and the second moiety being a pharmacokinetic modifying agent or targeting agent. Pharmaceutical compositions comprising the macromolecules and uses of the macromolecules for treating or suppressing the growth of a cancer is also described.

  本发明提供了一种大分子，包括具有表面氨基团的树状分子，至少一个含铂基团附着于其上。该大分子可以具有多个附着在表面氨基团上的含铂基团。或者，该大分子可以包括具有表面氨基团的树状分子，至少附着有两种不同的基团，第一种基团是含铂基团，第二种基团是药物动力学修饰剂或靶向剂。还描述了包括该大分子的制药组合物以及使用该大分子治疗或抑制癌症生长的用途。