N-(3,5-dichlorophenyl)-N'-(1,1-diethylpropyl)carbodiimide | 134169-05-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,5-dichlorophenyl)-N'-(1,1-diethylpropyl)carbodiimide
• CAS: 134169-05-4
• 化学式: C₁₄H₁₈Cl₂N₂
• 分子量: 285.216
• InChiKey: PRFOWUXDBWEYSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氰胺 、 N-(3,5-dichlorophenyl)-N'-(1,1-diethylpropyl)carbodiimide 在 N,N-二异丙基乙胺 作用下， 生成 N-Cyano-N'-(3,5-dichlorophenyl)-N''-(1,1-diethylpropyl)guanidine
  参考文献：
  名称：

  Biologically selective potassium channel openers having 1,1-diethylpropyl group

  摘要：

  To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00625-8
• 作为产物：
  描述：

  1,1-diethylpropylamine 在 四氯化碳 、 三乙胺 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 生成 N-(3,5-dichlorophenyl)-N'-(1,1-diethylpropyl)carbodiimide
  参考文献：
  名称：

  Biologically selective potassium channel openers having 1,1-diethylpropyl group

  摘要：

  To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00625-8

文献信息

• Novel cyanoguanidine derivatives
  申请人：Kanebo, Ltd.

  公开号：US05087640A1

  公开（公告）日：1992-02-11

  Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently fluorine, chlorine or bromine atom, and R.sup.3 is a C.sub.4 -C.sub.7 alkyl having at least a branch at the C.sub.1 position, exhibit K.sup.+ channel opening activity and are useful as hypotensive agents and coronary vasodilators.

  该公式的化合物：##STR1## 其中R.sup.1和R.sup.2分别是氟，氯或溴原子，R.sup.3是具有至少一个在C.sub.1位置处的支链的C.sub.4-C.sub.7烷基，具有K.sup.+通道开放活性，并且可用作降压剂和冠状血管扩张剂。
• US5087640A
  申请人：——

  公开号：US5087640A

  公开（公告）日：1992-02-11
• Biologically selective potassium channel openers having 1,1-diethylpropyl group
  作者：Kazuya Yoshiizumi、Norihiko Seko、Noriyasu Nishimura、Shoji Ikeda、Kohichiro Yoshino、Hirosato Kondo、Kazutaka Tanizawa

  DOI：10.1016/s0960-894x(98)00625-8

  日期：1998.12

  To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity. (C) 1998 Elsevier Science Ltd. All rights reserved.