Juglone (7) was converted into enone 13; this underwent radical cyclization to afford 15, which was aromatized to 16 and elaborated into (+)-nocardione A (1), the enantiomer of the naturally-occurring tyrosine phosphatase inhibitor (â)-nocardione A (2).
Juglone (7)被转化成烯酮13;烯酮13经过自由基环化后得到15,15芳香化后得到16,并被制成(+)-nocardione A (1),这是天然存在的
酪氨酸磷酸酶
抑制剂(â)-nocardione A (2)的对映体。