申请人:Pharmaxis Ltd.
公开号:US20150158813A1
公开(公告)日:2015-06-11
The preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the structure of Formula I:
is described. Methods of using compounds of Formula I, or pharmaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer, are also described.
本文描述了替代的3-卤代烯丙胺衍生物的制备和制药用途,作为具有公式I结构的SSAO/VAP-1抑制剂。还描述了使用公式I化合物或其药学上可接受的盐或衍生物治疗各种疾病的方法,例如炎症性疾病、眼部疾病、纤维化疾病、糖尿病诱导的疾病和癌症。