(+)-codamine | 21040-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (+)-codamine
• 英文别名: (S)-6-methoxy-2-methyl-1-veratryl-1,2,3,4-tetrahydro-isoquinolin-7-ol；(S)-6-Methoxy-2-methyl-1-veratryl-1,2,3,4-tetrahydro-isochinolin-7-ol；Optisch aktives 6-Methoxy-2-methyl-1-veratryl-1,2,3,4-tetrahydro-isochinolin-7-ol；Codamine；(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
• CAS: 21040-59-5
• 化学式: C₂₀H₂₅NO₄
• 分子量: 343.423
• InChiKey: OKORHWXYDBSYNO-INIZCTEOSA-N

物化性质

• 熔点：
  127°C
• 沸点：
  478.69°C (rough estimate)
• 密度：
  1.1867 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  重氮乙烷 、 乙醇 、 (+)-codamine 生成 6-methoxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
  参考文献：
  名称：

  Spaeth; Epstein, Chemische Berichte, 1926, vol. 59, p. 2794

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-Codamine 在 水 作用下， 以 异辛烷 、 苯 为溶剂， 反应 3.0h， 生成 Codamine, (-)- 、 (+)-codamine
  参考文献：
  名称：

  Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety, by use of immobilized lipase in organic solvent

  摘要：

  Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety by use of lipase immobilized with celite in water-saturated organic solvent gave the corresponding acylates and phenols in moderate optical yields.

  DOI：

  10.1016/s0957-4166(00)80135-4

文献信息

• Leithe, Chemische Berichte, 1930, vol. 63, p. 1501
  作者：Leithe

  DOI：——

  日期：——
• Host Cells and Methods for Oxidizing Aromatic Amino Acids
  申请人：The Regents of the University of California

  公开号：US20140134689A1

  公开（公告）日：2014-05-15

  The present invention provides for a method of producing an oxidation product of an aromatic amino acid in a genetically modified host cell. The method comprises culturing the genetically modified host cell under a suitable condition such that the culturing results in the genetically modified host cell producing oxidation product of an aromatic amino acid. The host cell comprises an enzyme capable of catalyzing the oxidation of aromatic amino acid. In some embodiments, the host cell is capable of biosynthesizing BH4 or MH4 from GTP.
• Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety, by use of immobilized lipase in organic solvent
  作者：Osamu Hoshino、Ruka Tanahashi、Mitsuhiro Okada、Hiroyuki Akita、Takeshi Oishi

  DOI：10.1016/s0957-4166(00)80135-4

  日期：1993.5

  Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety by use of lipase immobilized with celite in water-saturated organic solvent gave the corresponding acylates and phenols in moderate optical yields.
• Spaeth; Epstein, Chemische Berichte, 1926, vol. 59, p. 2794
  作者：Spaeth、Epstein

  DOI：——

  日期：——