Codamine, (-)- | 21052-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: Codamine, (-)-
• 英文别名: (1R)-1-[(3,4-dimethoxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
• CAS: 21052-10-8
• 化学式: C₂₀H₂₅NO₄
• 分子量: 343.423
• InChiKey: OKORHWXYDBSYNO-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (+/-)-Codamine 在 水 作用下， 以 异辛烷 、 苯 为溶剂， 反应 3.0h， 生成 Codamine, (-)- 、 (+)-codamine
  参考文献：
  名称：

  Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety, by use of immobilized lipase in organic solvent

  摘要：

  Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety by use of lipase immobilized with celite in water-saturated organic solvent gave the corresponding acylates and phenols in moderate optical yields.

  DOI：

  10.1016/s0957-4166(00)80135-4

文献信息

• Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety, by use of immobilized lipase in organic solvent
  作者：Osamu Hoshino、Ruka Tanahashi、Mitsuhiro Okada、Hiroyuki Akita、Takeshi Oishi

  DOI：10.1016/s0957-4166(00)80135-4

  日期：1993.5

  Enzymatic resolution of acylates of prochiral phenolic 1-aryl- and 1-arylalkyl-1,2,3,4-tetrahydroisoquinolinols, which possess a guaiacol-type moiety by use of lipase immobilized with celite in water-saturated organic solvent gave the corresponding acylates and phenols in moderate optical yields.