Acetyl-diethyl-phosphin | 20336-18-9

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: Acetyl-diethyl-phosphin
• 英文别名: 1-Diethylphosphanylethanone
• CAS: 20336-18-9
• 化学式: C₆H₁₃OP
• 分子量: 132.142
• InChiKey: DOQKZDHCOMCNHG-UHFFFAOYSA-N

物化性质

• 沸点：
  180-200 °C(Press: 1 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Acetyl-diethyl-phosphin 在 Trimethyl-stibin-sulfid 作用下， 生成 Acetyl-diethyl-phosphinthiooxid
  参考文献：
  名称：

  Spectroscopic Investigations of α-Keto Phosphorus Compounds

  摘要：

  测量了一些 α-酮磷化合物、(C2H5)2PCOR、(C2H5)2P(S)COR 和 [(C2H5)2CH3PCOR]+I- （R=C6H5 和 CH3）的核磁共振、红外和紫外光谱。羰基伸展频率和 n-π* 转变显示出相当大的红移，但其红移小于α-酮类有机硅化合物的红移。研究发现，羰基 π* 电平的降低主要是由于与磷原子空闲 d 轨道的相互作用引起的，这也是α-酮磷化合物 n-π* 转变发生红移的主要原因，尤其是在[(C2H5)2CH3PCOR]+I-中。发现羰基的 n 级上升幅度相当小。

  DOI：

  10.1246/bcsj.46.1803
• 作为产物：
  描述：

  乙酰溴 、 二乙基膦 在 barium carbonate 作用下， 生成 Acetyl-diethyl-phosphin
  参考文献：
  名称：

  Albers et al., Chemische Berichte, 1952, vol. 85, p. 239,248

  摘要：

  DOI：

文献信息

• Réactivité des dialcoyl(trialcoylgermyl)phosphines avec divers dérivés carbonylés
  作者：J. Satgé、C. Couret、J. Escudié

  DOI：10.1016/s0022-328x(00)84493-9

  日期：1970.10

  Aldehydes condense on the germaniumphosphorus bond of diethyl(triethylgermyl)phosphine with opening of the CO double bond and formation of phosphorus alkoxygermanes of the structure GeOCHP. The insertion derivatives of chloral and bromal are unstable and decompose via a β-elimination process.

  醛缩合在二乙基（三乙基锗）膦的锗with磷键上，并打开CO双键并形成GeOCHP结构的磷烷氧基锗烷。氯醛和溴醛的插入衍生物不稳定，并且会通过β消除过程分解。
• A method for quantitatively determining creatine kinase and a reagent therefor
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP0774514A1

  公开（公告）日：1997-05-21

  The object of the invention is to provide a reagent for quantitatively determining creatine kinase with improved storability in liquid form as well as a method for quantitatively determining creatine kinase with stable measurements. Disclosed are a method for quantitatively determining creatine kinase, which comprises activating creatine kinase in a sample in an aqueous medium in coexistence with a trivalent phosphorus compound and a sulfhydryl-containing compound and then determining creatine kinase activity; a method for stabilizing a sulfhydryl-containing compound, which comprises allowing a trivalent phosphorus compound to coexist with a sulfhydryl-containing compound; and a reagent for quantitatively determining creatine kinase, which comprises a trivalent phosphorus compound, a sulfhydryl-containing compound, and a reaction substrate for creatine kinase.

  本发明的目的是提供一种定量测定肌酸激酶的试剂，该试剂具有更好的液态贮存性，以及一种定量测定肌酸激酶的方法，其测量结果稳定。本发明公开了一种定量测定肌酸激酶的方法，该方法包括在水介质中与三价磷化合物和含巯基化合物共存，激活样品中的肌酸激酶，然后测定肌酸激酶活性；一种稳定含巯基化合物的方法，包括使三价磷化合物与含巯基化合物共存；以及一种定量测定肌酸激酶的试剂，包括三价磷化合物、含巯基化合物和肌酸激酶的反应底物。
• METHODS AND REAGENTS FOR QUANTITATIVELY DETERMINING ASCORBIC ACID
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP0926244A1

  公开（公告）日：1999-06-30

  The present invention relates to a method for the quantitative determination of ascorbic acid in a sample using ascorbate oxidase which catalyzes the reaction of reduced form of ascorbic acid with oxygen to form oxidized ascorbic acid and hydrogen peroxide (hereinafter the enzyme is referred to as ASOD), wherein the reaction of reduced ascorbic acid with oxygen in the presence of ASOD to form oxidized ascorbic acid and hydrogen peroxide and the reaction of the formed hydrogen peroxide with a chromogen in the presence of peroxidase to form a pigment are carried out in an aqueous medium in the same reaction system, and then the formed pigment is determined. The present invention also relates to a method for the determination of total ascorbic acid, wherein the enzyme reactions are carried out in the presence of a reducing agent which is capable of converting oxidized ascorbic acid into reduced ascorbic acid in said aqueous medium. The method enables the determination of total ascorbic acid at a low concentration. The present invention further relates to a method for the determination of total ascorbic acid, wherein oxidized ascorbic acid in said sample is reduced by the use of a reducing agent which is capable of converting oxidized ascorbic acid into reduced ascorbic acid, and then the enzyme reactions are carried out in the presence of a compound which is capable of deactivating the reducing agent. Furthermore, the present invention relates to a reagent and a kit for the determination of ascorbic acid suitable for use in the above methods. The method of the present invention is a simple method for the determination of ascorbic acid which is applicable to screening in clinical assays and which is capable of analyzing a large number of samples at the same time.

  本发明涉及一种利用抗坏血酸氧化酶定量测定样品中抗坏血酸的方法，抗坏血酸氧化酶可催化还原型抗坏血酸与氧反应生成氧化型抗坏血酸和过氧化氢（以下将该酶称为 ASOD）、在同一反应体系中，还原型抗坏血酸在 ASOD 的存在下与氧反应生成氧化型抗坏血酸和过氧化氢，生成的过氧化氢在过氧化物酶的存在下与发色剂反应生成色素，然后测定生成的色素。 本发明还涉及一种测定总抗坏血酸的方法，其中酶反应是在还原剂存在下进行的，还原剂能够在所述水介质中将氧化的抗坏血酸转化为还原的抗坏血酸。该方法可以测定低浓度的总抗坏血酸。 本发明还涉及一种测定总抗坏血酸的方法，其中通过使用能够将氧化抗坏血酸转化为还原抗坏血酸的还原剂来还原所述样品中的氧化抗坏血酸，然后在能够使还原剂失活的化合物存在下进行酶反应。 此外，本发明还涉及一种适用于上述方法的测定抗坏血酸的试剂和试剂盒。 本发明的方法是一种测定抗坏血酸的简单方法，适用于临床检测中的筛选，能够同时分析大量样品。
• Issleib; Priebe, Chemische Berichte, 1959, vol. 92, p. 3183,3188
  作者：Issleib、Priebe

  DOI：——

  日期：——
• US5817467A
  申请人：——

  公开号：US5817467A

  公开（公告）日：1998-10-06