3,5-dichloro-2-hydroxybenzenesulfinic acid | 125927-93-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-dichloro-2-hydroxybenzenesulfinic acid
• CAS: 125927-93-7
• 化学式: C₆H₄Cl₂O₃S
• 分子量: 227.068
• InChiKey: ADJSUQLUCKLDME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-dichloro-2-hydroxybenzenesulfinic acid 在 双氧水 作用下， 以 重水 为溶剂， 生成 3,5-二氯-2-羟基苯磺酸
  参考文献：
  名称：

  Sulfinic acids and related compounds. 24. Monothioquinone S,S-dioxides and their relation to convergent syntheses involving hydroxyarenesulfonyl chlorides

  摘要：

  DOI：

  10.1021/jo00295a062
• 作为产物：
  描述：

  3,5-二氯-2-羟基苯磺酰氯 在 三乙胺 、 4-甲苯硫酚 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以88%的产率得到3,5-dichloro-2-hydroxybenzenesulfinic acid
  参考文献：
  名称：

  Sulfinic acids and related compounds. 24. Monothioquinone S,S-dioxides and their relation to convergent syntheses involving hydroxyarenesulfonyl chlorides

  摘要：

  DOI：

  10.1021/jo00295a062

文献信息

• FIELD, LAMAR;LEE, CHEW, J. ORG. CHEM., 55,(1990) N, C. 2558-2563
  作者：FIELD, LAMAR、LEE, CHEW

  DOI：——

  日期：——
• COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME
  申请人：Eisenbarth George

  公开号：US20120195929A1

  公开（公告）日：2012-08-02

  The invention provides methods of preventing, treating or ameliorating autoimmune diseases such as diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
• [EN] COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME<br/>[FR] COMPOSÉS QUI MODULENT L'AUTO-IMMUNITÉ ET PROCÉDÉS POUR LES UTILISER
  申请人：UNIV COLORADO

  公开号：WO2010141883A1

  公开（公告）日：2010-12-09

  The invention provides methods of preventing, treating or ameliorating autoimmune diseases such as diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
• Sulfinic acids and related compounds. 24. Monothioquinone S,S-dioxides and their relation to convergent syntheses involving hydroxyarenesulfonyl chlorides
  作者：Lamar Field、Chew Lee

  DOI：10.1021/jo00295a062

  日期：1990.4