N-(3-chloro-4-trimethylsilylpyridin-2-yl)-N-methylamine | 468718-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(3-chloro-4-trimethylsilylpyridin-2-yl)-N-methylamine
• 英文别名: 3-chloro-N-methyl-4-trimethylsilylpyridin-2-amine
• CAS: 468718-63-0
• 化学式: C₉H₁₅ClN₂Si
• 分子量: 214.77
• InChiKey: RPRAXGCAEYUVAR-UHFFFAOYSA-N

物化性质

• 沸点：
  259.5±40.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.32
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(3-chloro-4-trimethylsilylpyridin-2-yl)-N-methylamine 在 4 A molecular sieve 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以80%的产率得到3-氯-N-甲基-2-吡啶胺
  参考文献：
  名称：

  Hetarynic synthesis and chemical transformation of dihydrodipyridopyrazines

  摘要：

  Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-halogenopyridines in the presence of the complex base NaNH2-tBuONa. Derivatizations of the new heterocycles are described. The anticancer activity of these compounds is also mentioned. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00310-1
• 作为产物：
  描述：

  N-(3-chloro-4-trimethylsilylpyridin-2-yl)-2,2-dimethylpropanamide 在 盐酸 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 N-(3-chloro-4-trimethylsilylpyridin-2-yl)-N-methylamine
  参考文献：
  名称：

  Hetarynic synthesis and chemical transformation of dihydrodipyridopyrazines

  摘要：

  Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-halogenopyridines in the presence of the complex base NaNH2-tBuONa. Derivatizations of the new heterocycles are described. The anticancer activity of these compounds is also mentioned. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00310-1

文献信息

• Hetarynic synthesis and chemical transformation of dihydrodipyridopyrazines
  作者：Stéphanie Blanchard、Ivan Rodriguez、Catherine Kuehm-Caubère、Pierre Renard、Bruno Pfeiffer、Gérald Guillaumet、Paul Caubère

  DOI：10.1016/s0040-4020(02)00310-1

  日期：2002.4

  Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-halogenopyridines in the presence of the complex base NaNH2-tBuONa. Derivatizations of the new heterocycles are described. The anticancer activity of these compounds is also mentioned. (C) 2002 Elsevier Science Ltd. All rights reserved.