trans-1-Methyl-2-phenyl-cyclopropan-carbonsaeure-(1)-amid | 10152-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-1-Methyl-2-phenyl-cyclopropan-carbonsaeure-(1)-amid
• 英文别名: 2-Phenyl-1-methyl-cyclopropancarbonsaeure-1-amid；(+/-)-1-methyl-2t-phenyl-cyclopropane-r-carboxylic acid amide；(+/-)-1-Methyl-2t-phenyl-cyclopropan-r-carbonsaeure-amid；(1R,2S)-1-methyl-2-phenylcyclopropane-1-carboxamide
• CAS: 10152-83-7；91132-12-6
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: NDFFYUFJJVYUQP-GXSJLCMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trans-1-Methyl-2-phenyl-cyclopropan-carbonsaeure-(1)-amid 在 氢氧化钾 、 臭氧 、 溶剂黄146 作用下， 生成 反式-1-甲基-1,2-环丙烷二羧酸
  参考文献：
  名称：

  Perold, Journal of the South African Chemical Institute, 1955, vol. 8, p. 1,9

  摘要：

  DOI：
• 作为产物：
  描述：

  1-Methyl-2-phenyl-cyclopropan-carbonsaeure-(1)-methylester 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 trans-1-Methyl-2-phenyl-cyclopropan-carbonsaeure-(1)-amid
  参考文献：
  名称：

  Kaiser,C. et al., Journal of medicinal and pharmaceutical chemistry, 1962, vol. 5, p. 1243 - 1265

  摘要：

  DOI：

文献信息

• COMPLEMENT PATHWAY MODULATORS AND USES THEREOF
  申请人：Altmann Eva

  公开号：US20150141455A1

  公开（公告）日：2015-05-21

  The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物I的公式：（I），本发明的化合物制备方法及其治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。
• Non-Aqueous Pigment Dispersions Using Dispersion Synergists
  申请人：Deroover Geert

  公开号：US20080308005A1

  公开（公告）日：2008-12-18

  A non-aqueous pigment dispersion comprising a diketopyrrolo-pyrrole pigment, a polymeric dispersant and a dispersion synergist in a non-aqueous dispersion medium characterized in that said dispersion synergist is a diketopyrrolo-pyrrole derivative according to Formula (I): wherein R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, an tert.-butyl group, a phenyl group, a cyano group and an acid group; R 4 , R 5 and R 6 are independently selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, an tert.-butyl group, a phenyl group and a cyano group; and characterized in that one of R 7 and R 8 is a group comprising two acid functions while the other one of R 7 and R 8 represents hydrogen.
• US9815819B2
  申请人：——

  公开号：US9815819B2

  公开（公告）日：2017-11-14
• [EN] COMPLEMENT PATHWAY MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE LA VOIE DU COMPLÉMENT ET LEURS UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2014002051A2

  公开（公告）日：2014-01-03

  The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
• Kaiser,C. et al., Journal of medicinal and pharmaceutical chemistry, 1962, vol. 5, p. 1243 - 1265
  作者：Kaiser,C. et al.

  DOI：——

  日期：——