1-(4-methylphenylamino)-3-phenoxy-2-propanol | 107701-96-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4-methylphenylamino)-3-phenoxy-2-propanol
• 英文别名: N-(2-Hydroxy-3-p-tolyloxypropyl)anilin；1-(4'-methylphenoxy)-3-(phenylamino)propan-2-ol；1-Phenylamino-3-p-tolyloxy-propan-2-ol；1-anilino-3-(4-methylphenoxy)propan-2-ol
• CAS: 107701-96-2
• 化学式: C₁₆H₁₉NO₂
• 分子量: 257.332
• InChiKey: OWWYAMYSCBINLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  463.7±35.0 °C(Predicted)
• 密度：
  1.146±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对叔丁基苯基1-(2,3-环氧)丙基醚 、 苯胺 在 SbCl₃ supported on montmorillonite K-10 作用下， 反应 0.1h， 以84%的产率得到1-(4-methylphenylamino)-3-phenoxy-2-propanol
  参考文献：
  名称：

  An Efficient Method for the Ring Opening of Epoxides with Aromatic Amines by Sb(III) Chloride under Microwave Irradiation

  摘要：

  在无溶剂和微波辐照条件下，蒙脱石 K-10 上支撑的 SbCl3 是环氧化物与芳香胺开环的高效催化剂，可高产率、高区域选择性地得到相应的 β-氨基醇

  DOI：

  10.3184/030823408x313582

文献信息

• LIGNIN DERIVED PHOTO-RESPONSIVE COATINGS
  申请人：EMPIRE TECHNOLOGY DEVELOPMENT LLC

  公开号：US20150307746A1

  公开（公告）日：2015-10-29

  Coating compositions that provide hydrophilic and self-cleaning properties upon exposure to an electromagnetic spectrum are disclosed. Coatings can include lignin-coumarate derivatives and/or lignin-azobenzene derivatives. When exposed to the electromagnetic spectrum, these compounds isomerize to cis-configuration which are hydrophilic in nature as compared to when these compounds are in their hydrophobic trans-state.

  本发明揭示了一种在电磁波谱曝光后具有亲水性和自洁性能的涂层组合物。涂层可以包括木质素-香豆酸衍生物和/或木质素-偶氮苯衍生物。当这些化合物暴露在电磁波谱中时，它们会异构化为顺式构型，与它们的疏水性反式状态相比，这些顺式构型具有亲水性质。
• Thiourea catalyzed aminolysis of epoxides under solvent free conditions. Electronic control of regioselective ring opening
  作者：Swapandeep Singh Chimni、Neeraj Bala、Vaibhav A. Dixit、Prasad V. Bharatam

  DOI：10.1016/j.tet.2010.02.053

  日期：2010.4

  A reactant economizing process for the regioselective aminolysis of epoxides using equimolar quantities of reactants catalyzed by the double hydrogen bond donor N,N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea is reported. Regioselectivity of the reaction is controlled by the electronic nature of the substituent on the styrene oxide, which has been substantiated on the basis of C-13 NMR data and DFT calculations. (C) 2010 Elsevier Ltd. All rights reserved.
• An efficient protocol for regioselective ring opening of epoxides using sulfated tungstate: application in synthesis of active pharmaceutical ingredients atenolol, propranolol and ranolazine
  作者：Sagar P. Pathare、Krishnacharya G. Akamanchi

  DOI：10.1016/j.tetlet.2013.09.065

  日期：2013.11

  Sulfated tungstate was found to be a new and highly efficient catalyst for opening of epoxide rings by amines to give beta-amino alcohols with high regioselectivity. Various advantages associated with this novel and environmental friendly protocol include solvent-free conditions, short reaction times, high product yields, simple workup procedure and easy recovery and reusability of the catalyst. This protocol has been applied for the synthesis of active pharmaceutical ingredients atenolol, propranolol and ranolazine. (C) 2013 Published by Elsevier Ltd.
• Microwave‐Assisted Cleavage of Epoxides with Amines in the Presence of the Catalytic Zn(OAc)₂/1,7‐Bis(2‐Benzoic Acid)‐1,4,7‐Trioxaheptane (ZnBBATOH)
  作者：Hossein Eshghi、Mohammad Rahimizadeh、Abolhassan Shoryabi

  DOI：10.1081/scc-200050944

  日期：2005.3

  We describe a highly regioselective ring opening of epoxides with aromatic amines in the presence of a catalytic amount of Zn(OAc)(2) and 1,7-bis(2-benzoic acid)-1,4,7-trioxaheptane under microwave irradiation. The yields of the amino alcohols a-re mostly good and the recovered catalyst could be reused several times.
• FURUKAWA MITSURU; OHKAWARA TADASHI; NOGUCHI YOSHIHIDE, CHEM. AND PHARM. BULL., 1978, 26, NO 11, 3556-3558
  作者：FURUKAWA MITSURU、 OHKAWARA TADASHI、 NOGUCHI YOSHIHIDE

  DOI：——

  日期：——