phenyl 4-(hydroxyisopropyl)phenyl ether | 4974-92-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl 4-(hydroxyisopropyl)phenyl ether
• 英文别名: p-Phenoxycumyl alcohol；2-(4-phenoxyphenyl)-2-hydroxypropane；2-(4-Phenoxyphenyl)-2-propanol；2-(4-Phenoxyphenyl)propan-2-ol
• CAS: 4974-92-9
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: DSIVPQAHDLURMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  phenyl 4-(hydroxyisopropyl)phenyl ether 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以94%的产率得到phenyl 4-(chloroisopropyl)phenyl ether
  参考文献：
  名称：

  Investigating the π-Facial Discrimination Phenomenon in the Conjugate Addition of Amines to Chiral Crotonates:  A Convenient Basis for the Rational Design of Chiral Auxiliaries

  摘要：

  This paper is concerned with the nature of the chiral inducer in the high pressure-induced conjugate addition of amines to auxiliary-tethered crotonates. Almost complete stereocontrol was obtained in the addition of diphenylmethanamine to crotonates derived from the ''arylmenthol'' auxiliaries 18a, 18c, and 4 bearing an o-methoxyphenyl, p-phenoxyphenyl, or beta-naphthyl substituent, respectively. This high efficiency has been attributed to the predominance of stacked conformations in such crotonates, a hypothesis supported by the H-1 NMR spectra, calculated energy of conformational optima of the corresponding crotonates, and X-ray crystal structure of 5a. The arene and enoate appendages are roughly coplanar, separated by 3.4-4 Angstrom. In contrast, only moderate selectivities could be achieved using various trans-2-arylcyclohexanols (27, 28, 2c, 29) as auxiliaries. In these cases the efficiency appears to be seriously compromised by the ''widening V'' arrangement exhibited by the two pi-systems, as shown in the X-ray crystal structures of crotonates 5 h and 5 k. The sense of stereochemical induction of this conjugate addition has been determined by condensing diphenylmethanamine with enantiopure crotonate (+)-5a. The adduct 9a was converted to amino alcohol (S)-11, of known configuration. This correlation is consistent with the preferential attack of the amine to the less sterically hindered enoate pi-face of(+)-5a, in its s-trans conformation. Finally, the stereochemistry of the proton transfer was determined by adding N,N-dideuteriodiphenylmethanamine to crotonate (+/-)-5a. The stereochemical outcome of this addition is consistent with the anti-addition of the incoming nitrogen nucleophile and the deuterium atom.

  DOI：

  10.1021/jo951414r
• 作为产物：
  描述：

  4-异丙基二苯醚 在 二甲基二环氧乙烷 作用下， 以 丙酮 为溶剂， 反应 24.0h， 生成 phenyl 4-(hydroxyisopropyl)phenyl ether
  参考文献：
  名称：

  Linear Free Energy Relationship Studies of the Dimethyldioxirane C-H Bond Insertion Reaction

  摘要：

  The relative rates of reaction of a series of p-substituted cumenes with dimethyldioxrane have been studied. The products are the corresponding cumyl alcohols. Treatment of the rate data with the Hammett substituent constants reveals that the insertion reaction is an electrophilic process with rho = -2.76. Similar treatment of the data with the Brown-Okamoto substituent constants gives rho(+) = -1.61. The second-order rate constants for the reaction of a series of substituted adamantanes with dimethyldioxirane were also determined. Again, the products are the corresponding adamantanols. The rate constants were correlated with several types of substituent constants. The best correlations were obtained with the Taft sigma(*) and sigma(I) constants which gave rho(*) = -1.08 and rho(I) -2.39, respectively. Thus, the insertion reaction in this aliphatic system is also electrophilic.

  DOI：

  10.1021/jo00122a059

文献信息

• RESIST COMPOSITION, METHOD FOR FORMING RESIST PATTERN, POLYPHENOLIC COMPOUND FOR USE IN THE COMPOSITION, AND ALCOHOLIC COMPOUND THAT CAN BE DERIVED THEREFROM
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US20160145231A1

  公开（公告）日：2016-05-26

  A resist composition containing a compound represented by the general formula (1) or (2), a method for forming a resist pattern using the composition, a polyphenolic compound for use in the composition, and an alcoholic compound that can be derived therefrom are described.

  描述了一种包含由通式（1）或（2）表示的化合物的光刻胶组合物，使用该组合物形成光刻胶图案的方法，用于该组合物的多酚化合物，以及可以由其衍生的醇化合物。
• OPTICAL COMPONENT FORMING COMPOSITION AND CURED PRODUCT THEREOF
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US20200262787A1

  公开（公告）日：2020-08-20

  The present invention provides an optical component forming composition comprising a tellurium-containing compound or a tellurium-containing resin.

  本发明提供了一种包括含碲化合物或含碲树脂的光学元件成型组合物。
• CYCLIC COMPOUND, PRODUCTION PROCESS THEREOF, RADIATION-SENSITIVE COMPOSITION AND RESIST PATTERN FORMATION METHOD
  申请人：Takasuka Masaaki

  公开号：US20120282546A1

  公开（公告）日：2012-11-08

  Disclosed are: a cyclic compound which has high solubility in a safe solvent, is highly sensitive, enables the formation of a resist pattern having a good shape, and rarely causes resist pattern collapse; a process for producing the cyclic compound; a radiation-sensitive composition containing the cyclic compound; and a resist pattern formation method using the composition. Specifically disclosed are: a cyclic compound having a specific structure; a process for producing the cyclic compound; a radiation-sensitive composition containing the compound; and a resist pattern formation method using the composition.

  本发明涉及一种具有高溶解度、高灵敏度、能够形成良好形状的抗蚀图案，且很少引起抗蚀图案崩塌的环状化合物；一种制备该环状化合物的方法；一种含有该环状化合物的辐射敏感组合物；以及使用该组合物的抗蚀图案形成方法。具体揭示了一种具有特定结构的环状化合物，制备该环状化合物的方法，含有该化合物的辐射敏感组合物以及使用该组合物的抗蚀图案形成方法。
• RESIST COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP1739485A1

  公开（公告）日：2007-01-03

  A radiation-sensitive composition containing a resist compound A, an acid generator B, and an acid crosslinking agent C. The resist compound A is (a) a polyphenol compound which is produced by the condensation of a C5-45 aromatic ketone or aromatic aldehyde with a C6-15 compound having from 1 to 3 phenolic hydroxyl groups, and, (b) its molecular weight is form 300 to 5000. The radiation-sensitive composition is solvent-soluble and exhibits a high sensitivity, high resolution, and high heat resistance.

  抗蚀剂化合物 A 是：(a) 一种多酚化合物，由 C5-45 芳香酮或芳香醛与具有 1 至 3 个酚羟基的 C6-15 化合物缩合而成；(b) 其分子量为 300 至 5000。辐射敏感组合物可溶于溶剂，具有高灵敏度、高分辨率和高耐热性。
• CYCLIC COMPOUND, MANUFACTURING METHOD THEREFOR, RADIATION-SENSITIVE COMPOSITION, AND METHOD FOR FORMING A RESIST PATTERN
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2474565A1

  公开（公告）日：2012-07-11

  A cyclic compound represented by formula (1): wherein L, R1, R', and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.

  式 (1) 所代表的环状化合物： 其中 L、R1、R'和 m 如说明书中所定义。式（1）的环状化合物对安全溶剂的溶解度高，灵敏度高，能形成具有良好轮廓的抗蚀图案。因此，该环状化合物可用作辐射敏感组合物的成分。