6-(5-ethoxycarbonylpentyl)-2',3'-isopropylidene-5'-deoxy-5'-methylthioadenosine | 866924-32-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-(5-ethoxycarbonylpentyl)-2',3'-isopropylidene-5'-deoxy-5'-methylthioadenosine
• 英文别名: ethyl 6-[[9-[(3aR,4R,6S,6aS)-2,2-dimethyl-6-(methylsulfanylmethyl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]purin-6-yl]amino]hexanoate
• CAS: 866924-32-5
• 化学式: C₂₂H₃₃N₅O₅S
• 分子量: 479.601
• InChiKey: AQJAIBKVDYOXHH-HAXDFEGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  6-(5-ethoxycarbonylpentyl)-2',3'-isopropylidene-5'-deoxy-5'-methylthioadenosine 在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 以39%的产率得到6-(5-ethoxycarbonylpentyl)-5'-deoxy-5'-methylthioadenosine
  参考文献：
  名称：

  Antibody to 5' -Deoxy-5' - Methylthioadenosine And Uses Thereof

  摘要：

  本发明提供了一种新的免疫原，一种具有对MTA（5'-去氧-5'-甲基硫腺苷）高特异性的新型抗体，使用该抗体制备的治疗方法和药物，以及测量精胺合成酶活性的敏感检测方法。

  公开号：

  US20070280946A1
• 作为产物：
  描述：

  6-溴己酸乙酯 、 5'-deoxy-2',3'-O-isopropylidene-5'-thiomethyladenosine 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以62.5%的产率得到6-(5-ethoxycarbonylpentyl)-2',3'-isopropylidene-5'-deoxy-5'-methylthioadenosine
  参考文献：
  名称：

  Antibody to 5' -Deoxy-5' - Methylthioadenosine And Uses Thereof

  摘要：

  本发明提供了一种新的免疫原，一种具有对MTA（5'-去氧-5'-甲基硫腺苷）高特异性的新型抗体，使用该抗体制备的治疗方法和药物，以及测量精胺合成酶活性的敏感检测方法。

  公开号：

  US20070280946A1

文献信息

• ANTIGEN-BINDING MOLECULE CONTAINING ANTIGEN-BINDING DOMAIN OF WHICH BINDING ACTIVITY TO ANTIGEN IS CHANGED DEPENDING ON MTA, AND LIBRARY FOR OBTAINING SAID ANTIGEN-BINDING DOMAIN
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20220153875A1

  公开（公告）日：2022-05-19

  An objective of the present invention is to provide antigen-binding molecules whose antigen-binding activity changes depending on the concentration of a small molecule compound specific to a target tissue, polynucleotides encoding the antigen-binding molecules, vectors containing the polynucleotides, cells carrying the vectors, libraries containing a plurality of the antigen-binding molecules that are different from one another, pharmaceutical compositions containing the antigen-binding molecules, methods of screening for the antigen-binding molecules, methods of producing the same, and the like. The present inventors discovered methylthioadenosine (MTA) as a small molecule compound specific to tumor tissue and created an antigen-binding domain whose antigen-binding activity changes depending on the concentration of MTA, or an antigen-binding molecule containing the antigen-binding domain, and also created a library containing a plurality of antigen-binding domains or antigen-binding molecules containing the antigen-binding domains that are different from one another and discovered that the above objective can be achieved by using the library. By using the antigen-binding molecules of the present disclosure, various diseases (for example, cancer) caused by target tissues (for example, tumor tissues) can be treated in a target tissue-specific manner.
• Antibody to 5' -Deoxy-5' - Methylthioadenosine And Uses Thereof
  申请人：Numata Yoshito

  公开号：US20070280946A1

  公开（公告）日：2007-12-06

  The present invention provides a new immunogen, a novel antibody having high specificity for MTA (5′-deoxy-5′-methylthioadenosine), methods of treatment and medicaments prepared using said antibody, and sensitive assays for measuring spermidine synthase activity.

  本发明提供了一种新的免疫原，一种具有对MTA（5'-去氧-5'-甲基硫腺苷）高特异性的新型抗体，使用该抗体制备的治疗方法和药物，以及测量精胺合成酶活性的敏感检测方法。