(1R,2S,3S,5S,7S,10S,11R,14S)-14-[tert-butyl(diphenyl)silyl]oxy-7,11-dimethyl-4-oxapentacyclo[8.8.0.02,7.03,5.011,16]octadec-16-en-6-one | 865441-02-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (1R,2S,3S,5S,7S,10S,11R,14S)-14-[tert-butyl(diphenyl)silyl]oxy-7,11-dimethyl-4-oxapentacyclo[8.8.0.02,7.03,5.011,16]octadec-16-en-6-one
• CAS: 865441-02-7
• 化学式: C₃₅H₄₄O₃Si
• 分子量: 540.818
• InChiKey: GURYGAIJGSYLJP-WHTUYNNDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.45
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1R,2S,3S,5S,7S,10S,11R,14S)-14-[tert-butyl(diphenyl)silyl]oxy-7,11-dimethyl-4-oxapentacyclo[8.8.0.02,7.03,5.011,16]octadec-16-en-6-one 在 titanium(IV) isopropylate 、 双(三甲基硅烷基)氨基钾 作用下， 生成 [(3S,8R,9S,10R,13S,14S,15S,16S,17E)-3-[tert-butyl(diphenyl)silyl]oxy-17-ethylidene-15-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-16-yl] acetate
  参考文献：
  名称：

  Synthesis of xestobergsterol A from dehydroepiandrosterone

  摘要：

  Xestobergsterol A, a potent inhibitor of histamine release, has been synthesized from dehydroepiandrosterone in a route that used introduction of a novel 15-oxygen functionality, side-chain construction via the orthoester Claisen rearrangement and TBAF-promoted epimerization-aldol condensation. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.07.042
• 作为产物：
  描述：

  (3S,8R,9S,10R,13S,14S)-3-[tert-butyl(diphenyl)silyl]oxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14-decahydrocyclopenta[a]phenanthren-17-one 在 叔丁基过氧化氢 、 苄基三甲基氢氧化铵 作用下， 以83%的产率得到(1R,2S,3S,5S,7S,10S,11R,14S)-14-[tert-butyl(diphenyl)silyl]oxy-7,11-dimethyl-4-oxapentacyclo[8.8.0.02,7.03,5.011,16]octadec-16-en-6-one
  参考文献：
  名称：

  Synthesis of xestobergsterol A from dehydroepiandrosterone

  摘要：

  Xestobergsterol A, a potent inhibitor of histamine release, has been synthesized from dehydroepiandrosterone in a route that used introduction of a novel 15-oxygen functionality, side-chain construction via the orthoester Claisen rearrangement and TBAF-promoted epimerization-aldol condensation. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.07.042

文献信息

• Synthesis of xestobergsterol A from dehydroepiandrosterone
  作者：Atsuko Nakamura、Yuko Kaji、Kana Saida、Michiko Ito、Yumi Nagatoshi、Noriyuki Hara、Yoshinori Fujimoto

  DOI：10.1016/j.tetlet.2005.07.042

  日期：2005.9

  Xestobergsterol A, a potent inhibitor of histamine release, has been synthesized from dehydroepiandrosterone in a route that used introduction of a novel 15-oxygen functionality, side-chain construction via the orthoester Claisen rearrangement and TBAF-promoted epimerization-aldol condensation. (c) 2005 Elsevier Ltd. All rights reserved.