(2-chloro-5-fluorobenzyl)zinc(II) bromide | 1072789-40-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-chloro-5-fluorobenzyl)zinc(II) bromide
• CAS: 1072789-40-2
• 化学式: C₇H₅BrClFZn
• 分子量: 288.862
• InChiKey: CWTVCYJLINTTET-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  2-氯-5-氟甲苯 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 生成 (2-chloro-5-fluorobenzyl)zinc(II) bromide
  参考文献：
  名称：

  Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives

  摘要：

  A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.022

文献信息

• PICOLINAMIDE INHIBITORS OF KINASES
  申请人：Vasudevan Anil

  公开号：US20120190681A1

  公开（公告）日：2012-07-26

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R 1 , R 2 , R 3 , A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

  本发明涉及公式（I）的化合物或药用可接受的盐，其中R1、R2、R3、A、B、Z、n和m在描述中有定义。本发明还涉及含有上述化合物的组合物，该组合物对抑制激酶如ALK有用，并且用于治疗癌症等疾病的方法。
• US8859546B2
  申请人：——

  公开号：US8859546B2

  公开（公告）日：2014-10-14
• [EN] PICOLINAMIDE INHIBITORS OF KINASES<br/>[FR] INHIBITEURS PICOLINAMIDES DE KINASES
  申请人：ABBOTT LAB

  公开号：WO2012100135A1

  公开（公告）日：2012-07-26

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.
• Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives
  作者：Manochehr Shahabi、Eva Schirmer、Karem Shanab、Theerachart Leepasert、Jana Ruzicka、Wolfgang Holzer、Helmut Spreitzer、Babette Aicher、Peter Schmidt、Lars Blumenstein、Gilbert Müller、Eckhard Günther

  DOI：10.1016/j.bmcl.2013.01.022

  日期：2013.3

  A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested. (C) 2013 Elsevier Ltd. All rights reserved.