2-噻吩-3-基苯酚 | 108932-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-噻吩-3-基苯酚
• 中文别名: 苯酚,2-(3-噻嗯基)-
• 英文名称: 2-(thiophen-3-yl)phenol
• 英文别名: 2-thiophen-3-ylphenol
• CAS: 108932-41-8
• 化学式: C₁₀H₈OS
• 分子量: 176.239
• InChiKey: VCRSXSFOKOVCRV-UHFFFAOYSA-N

物化性质

• 沸点：
  120 °C(Press: 10 Torr)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-噻吩-3-基苯酚 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-(2-Thiophen-3-yl-phenoxymethyl)-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  α1-Adrenoceptor Agonists: The Identification of Novel α1A Subtype Selective 2′-Heteroaryl-2-(phenoxymethyl)imidazolines

  摘要：

  Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00764-8
• 作为产物：
  描述：

  2'-甲氧基苯乙酮 在 吡啶盐酸盐 、 对甲苯磺酸 、 sulfur 、 magnesium 作用下， 以 苯 为溶剂， 反应 26.0h， 生成 2-噻吩-3-基苯酚
  参考文献：
  名称：

  Baldwin, Larry J.; Pakray, Sudabeh; Castle, Raymond N., Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 1667 - 1669

  摘要：

  DOI：

文献信息

• Palladium(<scp>ii</scp>)-catalyzed aerobic oxidative O–H/C–H isocyanide insertion: facile access to pyrrolo[2,1-<i>c</i>][1,4]benzoxazine derivatives
  作者：Liangliang Luo、Xiao-Pan Chen、Zhao-Feng Li、Yuan Zhou、You-Cai Xiao、Fen-Er Chen

  DOI：10.1039/d1ob00393c

  日期：——

  Palladium-catalyzed aerobic oxidative cyclizations of substituted 2-(1H-pyrrol-1-yl)phenols with isocyanides via an O–H/C–H insertion cascade have been developed. This strategy provides facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives in good to excellent yields under an O2 atmosphere. The notable features of this protocol include its mild reaction conditions, atom-economy, and broad functional

  钯催化的取代 2-(1 H -pyrrol-1-yl) 苯酚与异氰化物通过O-H/C-H 插入级联反应进行了有氧氧化环化。该策略提供了在 O 2气氛下以良好至优异产率轻松获得吡咯并[2,1- c ][1,4]苯并恶嗪衍生物的途径。该协议的显着特点包括其温和的反应条件、原子经济性和广泛的官能团耐受性。
• Cu-Catalyzed Dehydrogenative C–O Cyclization for the Synthesis of Furan-Fused Thienoacenes
  作者：Koichi Mitsudo、Yoshiaki Kobashi、Kaito Nakata、Yuji Kurimoto、Eisuke Sato、Hiroki Mandai、Seiji Suga

  DOI：10.1021/acs.orglett.1c01256

  日期：2021.6.4

  first Cu-catalyzed dehydrogenative C–O cyclization for the synthesis of furan-fused thienoacenes is described. A variety of heteroacenes including a thieno[3,2-b]furan or a thieno[2,3-b]furan skeleton were synthesized by intramolecular C–H/O–H coupling. The use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and

  描述了第一个用于合成呋喃稠合噻吩并的铜催化脱氢 C-O 环化反应。通过分子内C-H/O-H偶联合成了多种杂并苯，包括噻吩并[3,2- b ]呋喃或噻吩并[2,3- b ]呋喃骨架。N-甲基-2-吡咯烷酮、乙二醇单甲醚和甲苯的混合溶剂的使用对于抑制副反应和有效促进反应是必不可少的。还进行了双 C-O 环化以提供高度 π 膨胀的呋喃稠合噻吩。
• Beta 3 adrenergic agonists
  申请人：Sall Jon Daniel

  公开号：US20050080110A1

  公开（公告）日：2005-04-14

  The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity.

  本发明涉及一种β3肾上腺素能受体激动剂，其化学式为（I）；或其药用盐；该激动剂能够增加细胞中的脂解和能量消耗，因此，它可以用于治疗2型糖尿病和/或肥胖等疾病。
• 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20050037925A1

  公开（公告）日：2005-02-17

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen, atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substituteable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物由以下式子表示：[其中R1代表氢原子，卤素原子，烷基团等，R2代表氢原子，卤素原子，烷基团等，R3，R4，R5，R6和R7各自独立地代表氢原子，卤素原子，可替换的烷基团，可替换的烯基团，炔基团，可替换的环烷基团等，或R3，R4，R5，R6和R7可以形成一个环，该环可以被取代，该环由相邻的两个碳原子形成，这些碳原子与相应的取代基团相连，m和n各自独立地代表0或1。]其盐，酯衍生物及含有该化合物为有效成分的农药，以及含有该化合物和第二种草甘膦活性化合物为有效成分的除草剂组合物。
• 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20100041555A1

  公开（公告）日：2010-02-18

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物，其化学式为：[其中R1代表氢原子、卤素原子、烷基等，R2代表氢原子、卤素原子、烷基等，R3、R4、R5、R6和R7各自独立地代表氢原子、卤素原子、可替换的烷基、可替换的烯基、炔基、可替换的环烷基等，或R3、R4、R5、R6和R7可形成一个环，该环可以被取代，由它们中的相邻两个碳原子形成，各自带有相应的取代基，m和n各自独立地代表0或1。]其盐、酯衍生物和含有该化合物作为有效成分的农药，以及含有该化合物和第二种除草活性化合物作为有效成分的除草剂组合物。