Fmoc-cystamine | 896465-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-cystamine
• 英文别名: 9H-fluoren-9-ylmethyl N-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyldisulfanyl]ethyl]carbamate
• CAS: 896465-25-1
• 化学式: C₃₄H₃₂N₂O₄S₂
• 分子量: 596.771
• InChiKey: KPLRATQZHZBBKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Fmoc-cystamine 在 3,3,3-膦三基三丙酸 、 水 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以50%的产率得到N-9-fluorenylmethyloxycarbonyl-2-aminoethane thiol
  参考文献：
  名称：

  NOVEL MORPHINE DERIVATIVES

  摘要：

  本发明涉及新的吗啡-6-葡糖醛酸酯衍生物，其药用组合物及其用途。

  公开号：

  US20100075912A1
• 作为产物：
  描述：

  N-9-fluorenylmethyloxycarbonyl-2-aminoethane thiol 在 silica gel 、 三乙胺 作用下， 以 氘代氯仿 、 二氯甲烷 为溶剂， 反应 12.83h， 生成 Fmoc-cystamine
  参考文献：
  名称：

  A Three-Component Photoreversible Tag for Thiols

  摘要：

  A one-pot coupling of a 1,3-diketone, an aldehyde, and an alkanethiol has been developed to produce a protected sulfide. Through use of an o-nitrophenylbenzaldehyde, this method provides a one-step route to a photochemically reversible thiol-protecting group. The kinetics of photolysis were established using H-1 NMR analysis, which allows for the rate to be based on the entire reaction scheme.

  DOI：

  10.1021/jo0481396

文献信息

• Synthesis of selenocystine derivatives from cystine by applying the transformation reaction from disulfides to diselenides
  作者：Michio Iwaoka、Chie Haraki、Ryuta Ooka、Masahiro Miyamoto、Ai Sugiyama、Yumiko Kohara、Noriyoshi Isozumi

  DOI：10.1016/j.tetlet.2006.03.177

  日期：2006.6

  A stepwise conversion of a disulfide (SS) to a diselenide (SeSe) bond through the corresponding iodide intermediate was implemented and was applied to the synthesis of selenocystamine and l-selenocystine derivatives from cystamine and l-cystine, respectively, in moderate yields.

  通过相应的碘化物中间体将二硫键（SS）逐步转变为二硒键（SeSe），并以中等收率将其分别用于从胱胺和l-胱氨酸合成硒代半胱胺和1-硒代半胱氨酸衍生物。
• A dismantlable photoadhesion system fabricated by an anionic UV curing of epoxy resins with a base amplifier having a disulfide bond
  作者：Masahiro Furutani、Ayaru Kakinuma、Koji Arimitsu

  DOI：10.1002/pola.28898

  日期：2018.1.15

  A base amplifier (BA) that autocatalytically generates a diamine having a disulfide bond has been developed. Diamines generated from this BA are integrated into cross‐linked networks of epoxy resins that also have disulfide bonds. Anionic UV curing is performed using a photobase generator, the BA and the epoxy resins, and cured films are obtained after UV irradiation and subsequent heating at 160 °C

  已经开发了可自动催化产生具有二硫键的二胺的基础放大器（BA）。此BA产生的二胺被整合到也具有二硫键的环氧树脂的交联网络中。使用光碱产生剂，BA和环氧树脂进行阴离子UV固化，并在UV辐射并随后在160°C加热后获得固化膜。此外，该固化系统已成功应用于两个不锈钢基材的粘合，该粘合可通过缓慢加热和剪切力消除。©2017 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2018，56，237-241
• NOVEL MORPHINE DERIVATIVES
  申请人：Larbouret Karine

  公开号：US20100075912A1

  公开（公告）日：2010-03-25

  The present invention relates to new morphine-6-glucuronide derivatives, to pharmaceutical compositions thereof and uses thereof.

  本发明涉及新的吗啡-6-葡糖醛酸酯衍生物，其药用组合物及其用途。
• A Three-Component Photoreversible Tag for Thiols
  作者：Kristine M. Clarke、James J. La Clair、Michael D. Burkart

  DOI：10.1021/jo0481396

  日期：2005.4.1

  A one-pot coupling of a 1,3-diketone, an aldehyde, and an alkanethiol has been developed to produce a protected sulfide. Through use of an o-nitrophenylbenzaldehyde, this method provides a one-step route to a photochemically reversible thiol-protecting group. The kinetics of photolysis were established using H-1 NMR analysis, which allows for the rate to be based on the entire reaction scheme.