2,3,4-trimethoxybenzoic anhydride | 111798-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4-trimethoxybenzoic anhydride
• 英文别名: 2,3,4-trimethoxy-benzoic acid-anhydride；2,3,4-Trimethoxy-benzoesaeure-anhydrid；Trimethoxybenzoic anhydride；(2,3,4-trimethoxybenzoyl) 2,3,4-trimethoxybenzoate
• CAS: 111798-15-3
• 化学式: C₂₀H₂₂O₉
• 分子量: 406.389
• InChiKey: RSRWINFPRJPFMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  98.8
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,3,4-trimethoxybenzoic anhydride 在 sodium-<2,3,4-trimethoxy benzoate> 、 potassium carbonate 、 丙酮 作用下， 生成 3,5,7-trimethoxy-2-(2,3,4-trimethoxy-phenyl)-chromen-4-one
  参考文献：
  名称：

  Ahluwalia et al., Proceedings - Indian Academy of Sciences, Section A, 1958, # 47, p. 230,232

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,4-三甲氧基苯甲酸 在 吡啶 、 氯化亚砜 、 乙醚 作用下， 生成 2,3,4-trimethoxybenzoic anhydride
  参考文献：
  名称：

  Ahluwalia et al., Proceedings - Indian Academy of Sciences, Section A, 1958, # 47, p. 230,232

  摘要：

  DOI：

文献信息

• Modified gangliosides and the functional derivatives thereof
  申请人：FIDIA S.p.A.

  公开号：EP0433112A1

  公开（公告）日：1991-06-19

  N-acyl-N,N′-di-lysogangliosides, N′-acyl-N,N′-di-­lysogangliosides and N,N′-diacyl-N,N′-di-­lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at least one of the two acyl groups is not aliphatic, and their preparation are disclosed. Also disclosed is the preparation of the esters, inner esters, amides and hydroxy peracylates of these compounds and salts thereof. These compounds are useful in the treatment of pathologies of the central and peripheral nervous systems.

  N-acyl-N,N′-di-lysogangliosides, N′-acyl-N,N′-di-lysogangliosides和N,N′-diacyl-N,N′-di-lysogangliosides，其中酰基来自脂肪族、芳香族、脂环族、脂环族或杂环族的有机酸，并且其中至少有一个酰基不是脂肪族、本发明公开了两个酰基中至少有一个不是脂肪族的二乙酰基-N，N′-二赖糖糖苷及其制备方法。此外，还公开了这些化合物的酯、内酯、酰胺和羟基过酰基化合物及其盐的制备方法。这些化合物可用于治疗中枢和外周神经系统的疾病。
• BHARDWAJ, D. K.;BANSAL, M. C.;BHALLA, S.;SCRAWAT, V. S.;TYAGI, R. C., PROC. INDIAN NAT. SCI. CAD. A. A., 54,(1988) N, C. 635-637
  作者：BHARDWAJ, D. K.、BANSAL, M. C.、BHALLA, S.、SCRAWAT, V. S.、TYAGI, R. C.

  DOI：——

  日期：——
• US5264424A
  申请人：——

  公开号：US5264424A

  公开（公告）日：1993-11-23
• US5424294A
  申请人：——

  公开号：US5424294A

  公开（公告）日：1995-06-13
• Effects of Flavonoids on Cell Proliferation and Caspase Activation in a Human Colonic Cell Line HT29:  An SAR Study
  作者：Jean-Baptiste Daskiewicz、Flore Depeint、Lionel Viornery、Christine Bayet、Geraldine Comte-Sarrazin、Gilles Comte、Jennifer M. Gee、Ian T. Johnson、Karine Ndjoko、Kurt Hostettmann、Denis Barron

  DOI：10.1021/jm040770b

  日期：2005.4.1

  A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A- and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. With respect to structural modification of flavonoids, C-isoprenylation was by far the most effective, with substitution at the 8-position and longer chains, such as geranyl giving the best results. Finally, most compounds that significantly reduced cell survival also increased caspase activity, suggesting that at least part of their antiproliferative activity might be attributable to an apoptotic response.