2-[(2-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid | 326611-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid
• CAS: 326611-23-8
• 化学式: C₁₅H₁₂ClNO₃S
• mdl: MFCD01238951
• 分子量: 321.784
• InChiKey: MHALOUDQCZKXIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(2-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid 、 环丙基甲胺 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 四氢呋喃 为溶剂， 生成 2-[(2-chlorobenzoyl)amino]-N-(cyclopropylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
  参考文献：
  名称：

  Structure–activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action

  摘要：

  SAR studies were performed ona series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.087
• 作为产物：
  描述：

  2-氨基-5,6-二氢-4H-环戊并[b]噻吩-3-甲酸乙酯 在 吡啶 、 potassium hydroxide 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 2-[(2-chlorobenzoyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid
  参考文献：
  名称：

  Structure–activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action

  摘要：

  SAR studies were performed ona series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.087

文献信息

• Structure–activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action
  作者：Yithachu Thur、Amit Bhalerao、Zaki Munshi、Nisha Pansare、Klaus Mann、Guido Hanauer、Hans-Peter Kley、Sandra Nappe、Cornelia Weiss-Haljiti、Claude Ostermann、Christof Zitt、Michaela Schaefer、Dibyendu Mondal、Afsar Ali Siddiki、Velavan Armugam、Vinod Gudaghe、Mahendra Gupta、Pramila Rayudu、Frank M. Dautzenberg、Koushik Das Sarma

  DOI：10.1016/j.bmcl.2012.10.087

  日期：2012.12

  SAR studies were performed ona series of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia. (C) 2012 Elsevier Ltd. All rights reserved.
• Discovery of novel tetrahydrobenzothiophene derivatives as MSBA inhibitors for antimicrobial agents
  作者：Shuchen Pei、Lin Lai、Wanlin Sun、Zhaoyang Lu、Jielei Hao、Yuheng Liu、Wen Wu、Shan Guan、Xiaoyan Su

  DOI：10.1016/j.bioorg.2023.106932

  日期：2024.1