1-(sec-butyl)-4-phenoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(sec-butyl)-4-phenoxybenzene
• 英文别名: (4-sec-butyl-phenyl)-phenyl ether；(+/-)-Phenyl-(4-sek.-butyl-phenyl)-aether；(4-sec-Butyl-phenyl)-phenyl-aether；1-Butan-2-yl-4-phenoxybenzene
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: AKMXCMSVKVTORS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二苯醚 、 水杨酸丁酯 在 三氟化硼 作用下， 生成 1-(sec-butyl)-4-phenoxybenzene
  参考文献：
  名称：

  ORGANIC REACTIONS WITH BORON FLUORIDE. XVII.^* REARRANGEMENT OF ALKYL SALICYLATES AND THE REACTION OF ALCOHOLS WITH SALICYLIC ACID

  摘要：

  DOI：

  10.1021/jo01226a007

文献信息

• Thorpe-Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides
  作者：Matthew J. O'Neill、Tim Riesebeck、Josep Cornella

  DOI：10.1002/anie.201804479

  日期：2018.7.16

  Presented herein is a general protocol for the alkylation of simple aryl fluorides with unbiased secondary Grignard reagents by means of nickel catalysis. This study revealed a general Thorpe–Ingold effect in the ligand backbone which confers a high degree of selectivity for the secondary carbon center in the C−C coupling event. This protocol is characterized by mild reaction conditions, robustness

  本文提出了通过镍催化用无偏的二次格氏试剂将简单的芳基氟化物烷基化的一般方案。这项研究揭示了配体主链上普遍的索普-英戈尔德效应，在CC偶合事件中赋予了次级碳中心高度的选择性。该协议的特点是反应条件温和，稳健且简单。富电子和缺电子的芳基氟化物都是该转化的合适候选物。同样适合的是各种杂环，允许偶联而在亲电子位点没有过度烷基化。
• FATTY ACID COX INHIBITOR DERIVATIVES AND THEIR USES
  申请人：Milne Jill C.

  公开号：US20130065934A1

  公开（公告）日：2013-03-14

  The invention relates to fatty acid COX inhibitor derivatives; compositions comprising an effective amount of a fatty acid COX inhibitor derivative; and methods for treating or preventing a metabolic, autoimmune, inflammatory, or neurodegenerative disorder comprising the administration of an effective amount of a fatty acid COX inhibitor derivative.

  本发明涉及脂肪酸COX抑制剂衍生物；包含有效量脂肪酸COX抑制剂衍生物的组合物；以及治疗或预防代谢性、自身免疫性、炎症性或神经退行性疾病的方法，其中包括给予有效量的脂肪酸COX抑制剂衍生物。
• US2170809
  申请人：——

  公开号：——

  公开（公告）日：——
• 6-11 Bicyclic Ketolide Derivatives
  申请人：Or Yat Sun

  公开号：US20120035352A1

  公开（公告）日：2012-02-09

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
• US20140342275A1
  申请人：——

  公开号：US20140342275A1

  公开（公告）日：2014-11-20