6-O-allyl-5-allyloxymethyl-2,2,7,8-tetramethyl-chroman-6-ol | 1276099-15-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-O-allyl-5-allyloxymethyl-2,2,7,8-tetramethyl-chroman-6-ol
• CAS: 1276099-15-0
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.441
• InChiKey: IMOOYPANLHJSRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.67
• 重原子数：
  23.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  6-O-allyl-5-allyloxymethyl-2,2,7,8-tetramethyl-chroman-6-ol 、 (2R)-3,4-dibenzyloxy-2-[(1S)-1,2-dihydroxyethyl]-2H-furan-5-one 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以24%的产率得到6-O-allyl-5-(2,3-di-O-benzyl-L-ascorbate-6-oxy)-methyl-2,2,7,8-tetramethyl-chroman-6-ol
  参考文献：
  名称：

  Transformations of chromanol and tocopherol and synthesis of ascorbate conjugates

  摘要：

  alpha-Tocopherol and as a model compound pentamethylchromanol could be transferred into simple and more complex 5a-ether derivatives including galactopyranose as well as ascorbic acid conjugates. Following elaboration of a glucopyranoside spacer element this could be used for tethering the vitamin E and the vitamin C components to give novel conjugates for subsequent biostudies concerning their proposed synergism of antioxidant properties in tissues. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.066
• 作为产物：
  描述：

  5-(Chloromethyl)-2,2,7,8-tetramethyl-3,4-dihydrochromen-6-ol 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 18.5h， 生成 6-O-allyl-5-allyloxymethyl-2,2,7,8-tetramethyl-chroman-6-ol
  参考文献：
  名称：

  Transformations of chromanol and tocopherol and synthesis of ascorbate conjugates

  摘要：

  alpha-Tocopherol and as a model compound pentamethylchromanol could be transferred into simple and more complex 5a-ether derivatives including galactopyranose as well as ascorbic acid conjugates. Following elaboration of a glucopyranoside spacer element this could be used for tethering the vitamin E and the vitamin C components to give novel conjugates for subsequent biostudies concerning their proposed synergism of antioxidant properties in tissues. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.066

文献信息

• Transformations of chromanol and tocopherol and synthesis of ascorbate conjugates
  作者：Martina Lahmann、Joachim Thiem

  DOI：10.1016/j.tet.2010.12.066

  日期：2011.3

  alpha-Tocopherol and as a model compound pentamethylchromanol could be transferred into simple and more complex 5a-ether derivatives including galactopyranose as well as ascorbic acid conjugates. Following elaboration of a glucopyranoside spacer element this could be used for tethering the vitamin E and the vitamin C components to give novel conjugates for subsequent biostudies concerning their proposed synergism of antioxidant properties in tissues. (C) 2011 Elsevier Ltd. All rights reserved.