6-p-Tolyl-2-(N-piperidinomethyl)-4,5-dihydro-3(2H)-pyridazinone | 58112-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-p-Tolyl-2-(N-piperidinomethyl)-4,5-dihydro-3(2H)-pyridazinone
• 英文别名: 6-(4-methylphenyl)-2-(piperidin-1-ylmethyl)-4,5-dihydropyridazin-3(2H)-one；2-piperidin-1-ylmethyl-6-p-tolyl-4,5-dihydro-2H-pyridazin-3-one；6-(4-methylphenyl)-2-(1-piperidinylmethyl)-4,5-dihydro-3(2H)-pyridazinone；6-(4-methylphenyl)-2-(piperidin-1-ylmethyl)-4,5-dihydropyridazin-3-one
• CAS: 58112-75-7
• 化学式: C₁₇H₂₃N₃O
• 分子量: 285.389
• InChiKey: ARGPRXXFLZVSIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 聚合甲醛 、 2,3,4,5-四氢-6-(4-甲基苯基)-3-哒嗪酮 以 乙醇 为溶剂， 反应 24.0h， 以41%的产率得到6-p-Tolyl-2-(N-piperidinomethyl)-4,5-dihydro-3(2H)-pyridazinone
  参考文献：
  名称：

  Synthesis, characterization and antihypertensive activity of pyridazinone derivatives

  摘要：

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.

  DOI：

  10.1016/j.ejmech.2010.02.003

文献信息

• SAYED A. A.; JAHINE H.; ZAHER H. A.; SHERIF O., INDIAN J. CHEM. <IJOC-AP>, 1975, 13, NO 11, 1142-1144
  作者：SAYED A. A.、 JAHINE H.、 ZAHER H. A.、 SHERIF O.

  DOI：——

  日期：——
• KADDAH A. M.; KHALIL A. M., INDIAN J. CHEM., 1977, B 15, NO 11, 1025-1028
  作者：KADDAH A. M.、 KHALIL A. M.

  DOI：——

  日期：——
• Synthesis, characterization and antihypertensive activity of pyridazinone derivatives
  作者：Anees A. Siddiqui、Ravinesh Mishra、Mohammad Shaharyar

  DOI：10.1016/j.ejmech.2010.02.003

  日期：2010.6

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.