7-Methyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-5-on | 27943-33-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 7-Methyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-5-on
• 英文别名: 7-methyl-3,4-dihydro-2H-benzo[f][1,4]thiazepin-5-one；7-methyl-3,4-dihydro-2H-1,4-benzothiazepin-5-one
• CAS: 27943-33-5
• 化学式: C₁₀H₁₁NOS
• 分子量: 193.269
• InChiKey: KHCUZXWSQNQUKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-Methyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-5-on 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 生成 7-Methyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-5-on-1,1-dioxid
  参考文献：
  名称：

  Wuensch,K.-H. et al., Chemische Berichte, 1970, vol. 103, p. 2302 - 2307

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲基硫代苯并二氢吡喃-4-酮 在 三(2-氯乙基)胺 、 硫酸 作用下， 以 苯 为溶剂， 生成 7-Methyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-5-on 、 7-Methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-on
  参考文献：
  名称：

  Wuensch,K.-H. et al., Chemische Berichte, 1970, vol. 103, p. 2302 - 2307

  摘要：

  DOI：

文献信息

• Compounds And Methods For Modulating Activity Of Calcium Release Channels
  申请人：Abramson Jonathan J.

  公开号：US20120101085A1

  公开（公告）日：2012-04-26

  The present teachings provide compounds of Formulae I and II: and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R 1 , R 1′ , R 2 , R 2′ , R 3 , R 3′ , and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca 2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.

  本发明提供了公式I和II的化合物：以及其药学上可接受的盐，水合物，配合物，酯和前药，其中R1，R1'，R2，R2'，R3，R3'和X如本文所定义。本发明还提供了制备公式I和II化合物的方法，以及治疗与RyR相关的疾病和疾病的方法，包括向需要的受体中投与公式I或II的化合物的治疗有效量。此外，本发明涉及通过将公式I或II的化合物与Ryanodine受体接触，以降低Ryanodine受体的开放概率和减少Ca2+释放（例如进入细胞质）的方法。
• RYANODINE CHANNEL BINDERS AND USES THEREOF
  申请人：Corey Elias James

  公开号：US20110263569A1

  公开（公告）日：2011-10-27

  Increasing the affinity of calstabin-2 for the cardiac calcium channel RyR2 and thereby stabilizing the channel in the closed state has recently been identified as novel mechanism for treating heart failure, particularly ventricular arrhythmias. JTV-519, a 1,4-benzothiazepine derivative, has been shown to stabilize the calstabin2/RyR2 complex. Novel derivatives of JTV-519 that may be useful in treatment or prevention of heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmias are provided. Synthetic methodology and intermediates in the synthesis of the inventive JTV-519 derivatives are also described.

  增加calstabin-2与心脏钙通道RyR2之间的亲和力，从而稳定通道处于关闭状态，最近被确认为治疗心力衰竭、特别是心室心律失常的新机制。已经证明，1,4-苯并噻唑衍生物JTV-519可以稳定calstabin2/RyR2复合物。提供了JTV-519的新衍生物，这些衍生物可能在治疗或预防心力衰竭、心房颤动或运动引起的心律失常中有用。还描述了创新JTV-519衍生物的合成方法和中间体。
• Verfahren zur Kernchlorierung von aromatischen Kohlenwasserstoffen
  申请人：BAYER AG

  公开号：EP0368063B1

  公开（公告）日：1992-06-10
• AGENTS FOR PREVENTING AND TREATING DISORDERS INVOLVING MODULATION OF THE RYANODINE RECEPTORS
  申请人：Marks Andrew Robert

  公开号：US20110172190A1

  公开（公告）日：2011-07-14

  The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.
• US4990707A
  申请人：——

  公开号：US4990707A

  公开（公告）日：1991-02-05