N,N'-bis(1H-benzimidazol-2-yl)nonanediamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N,N'-bis(1H-benzimidazol-2-yl)nonanediamide
• 化学式: C₂₃H₂₆N₆O₂
• 分子量: 418.498
• InChiKey: SJONIAPCMTYQRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基苯并咪唑 、 壬二酰氯 生成 N,N'-bis(1H-benzimidazol-2-yl)nonanediamide
  参考文献：
  名称：

  Biological evaluation of hepatitis c virus helicase inhibitors

  摘要：

  A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biological activity. The development of a robust HCV helicase assay is also described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00263-3

文献信息

• Biological evaluation of hepatitis c virus helicase inhibitors
  作者：Chee Wee Phoon、Poh Yong Ng、Anthony E Ting、Su Ling Yeo、Mui Mui Sim

  DOI：10.1016/s0960-894x(01)00263-3

  日期：2001.7

  A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biological activity. The development of a robust HCV helicase assay is also described. (C) 2001 Elsevier Science Ltd. All rights reserved.