(R)-9-[(2-benzylaminophosphonomethoxy)propyl]adenine | 1619914-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (R)-9-[(2-benzylaminophosphonomethoxy)propyl]adenine
• 英文别名: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(benzylamino)phosphinic acid
• CAS: 1619914-55-4
• 化学式: C₁₆H₂₁N₆O₃P
• 分子量: 376.355
• InChiKey: DTFIIYTUBABQMB-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphinic acid 、 苄胺 在 N,O-双三甲硅基乙酰胺 作用下， 以 四氯化碳 为溶剂， 反应 16.0h， 生成 [P¹-(R)-9-[(2-benzylaminophosphonomethoxy)propyl]adenine-P²-(R)-9-[(2-benzylaminophosphonomethoxy)propyl]adenine] 、 (R)-9-[(2-benzylaminophosphonomethoxy)propyl]adenine
  参考文献：
  名称：

  (R)-9-[2-(Hydroxyphosphinylmethoxy)propyl]adenine as the precursor molecule for antivirals

  摘要：

  The biological importance and practical significance of phosphonates have been a major driving force for antiviral research in the past two decades. We describe in this Letter the potential of the H-phosphinate derivative (R)-9-[2-(hydroxyphosphinylmethoxy)propyl]adenine as the versatile synthetic intermediate in the preparation of N-alkylphosphonamidate and alkylphosphonate series. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.05.061

文献信息

• (R)-9-[2-(Hydroxyphosphinylmethoxy)propyl]adenine as the precursor molecule for antivirals
  作者：Loic Roux、Bruno Canard、Karine Alvarez

  DOI：10.1016/j.tetlet.2014.05.061

  日期：2014.7

  The biological importance and practical significance of phosphonates have been a major driving force for antiviral research in the past two decades. We describe in this Letter the potential of the H-phosphinate derivative (R)-9-[2-(hydroxyphosphinylmethoxy)propyl]adenine as the versatile synthetic intermediate in the preparation of N-alkylphosphonamidate and alkylphosphonate series. (C) 2014 Elsevier Ltd. All rights reserved.