Methyl 2-benzamidoacetate;hydrochloride | 1377733-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-benzamidoacetate;hydrochloride
• CAS: 1377733-34-0
• 化学式: C₁₀H₁₁NO₃*ClH
• 分子量: 229.663
• InChiKey: UTYMHOXDTSNXGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.01
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  55.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 2-benzamidoacetate;hydrochloride 在 一水合肼 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 (E)-N-(2-(2-((1H-indol-3-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide
  参考文献：
  名称：

  Synthesis and Comparison of Antioxidant Properties of Indole-Based Melatonin Analogue Indole Amino Acid Derivatives

  摘要：

  Increased levels of reactive oxygen species attributed to oxidative stress have been found to be responsible for the development of some vital diseases such as cardiovascular, neurodegenerative and autoimmune diseases. Recently, it was observed that melatonin is a highly important antioxidant, and melatonin analogues are under investigation to find out improved antioxidant activity. In this study, 14 melatonin ‐based analogue indole amino acid and N‐protected amino acid derivatives were synthesized and elucidated spectrometrically. To investigate the antioxidant activity of the synthesized compounds and to compare with melatonin, butylhydroxytoluene and vitamin E, lipid peroxidation inhibition and 2,2‐diphenyl‐1‐picrylhydrazyl radical‐scavenging activities were tested. The results indicated that the synthesized new indole amino acid derivatives have similar activities to melatonin in 2,2‐diphenyl‐1‐picrylhydrazyl radical‐scavenging activity assay but more potent activities in lipid peroxidation inhibition assay.

  DOI：

  10.1111/j.1747-0285.2011.01216.x

文献信息

• Dipeptides and process
  申请人：W.R. Grace & Co.-Conn.

  公开号：EP0220923A2

  公开（公告）日：1987-05-06

  Hydroxy-aspartame and derivatives thereof are made by enzymatic coupling of phenylserine or a derivative thereof with aspartic acid or a derivative thereof. The invention also provides novel phenylserine esters which may be made (1) from benzaldehyde and a glycine ester using serine hydroxymethyltransferase or (2) from methyl benzoylacetate. Hydroxy-aspartame and its derivatives may be hydrogenated to produce aspartame or a derivative thereof.

  羟基阿斯巴甜及其衍生物是由苯丝氨酸或其衍生物与天冬氨酸或其衍生物经酶偶联而成。本发明还提供了新型的苯基丝氨酸酯，可(1)使用丝氨酸羟甲基转移酶从苯甲醛和甘氨酸酯制得，或(2)从苯甲酰乙酸甲酯制得。羟基天门冬酰胺及其衍生物可通过氢化制得天门冬酰胺或其衍生物。
• Dipeptide analogs of aspertame and process to prepare them as well as a new preparation of aspertame
  申请人：HAMPSHIRE CHEMICAL CORP.

  公开号：EP0574028A1

  公开（公告）日：1993-12-15

  Process of making a dipeptide of the formula wherein B represents hydrogen or Q; Q represents an amino acid protective group; V represents hydrogen or an alkyl group having 1, 2, 3 or 4 carbon atoms; and C¹ and C² have the common natural configuration of naturally occurring amino acids.

  式二肽的制作过程 其中 B 代表氢或 Q；Q 代表氨基酸保护基；V 代表氢或具有 1、2、3 或 4 个碳原子的烷基；C¹ 和 C² 具有天然氨基酸的共同天然构型。
• US4710583A
  申请人：——

  公开号：US4710583A

  公开（公告）日：1987-12-01
• US4810817A
  申请人：——

  公开号：US4810817A

  公开（公告）日：1989-03-07
• US4873359A
  申请人：——

  公开号：US4873359A

  公开（公告）日：1989-10-10