Bis(2-amino-4,6-dichlorophenyl)disulfide | 227012-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis(2-amino-4,6-dichlorophenyl)disulfide
• CAS: 227012-70-6
• 化学式: C₁₂H₈Cl₄N₂S₂
• 分子量: 386.153
• InChiKey: MSFPRUQYKPQTGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.26
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.04
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  Bis(2-amino-4,6-dichlorophenyl)disulfide 在 sodium hydroxide 、 potassium permanganate 、 水 、 溶剂黄146 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis of 2-substituted-6,8-dichloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-1,1-dioxides and -1-oxides as glycine-NMDA receptor antagonists

  摘要：

  A number of 2-substituted-3,4-dihydro-3-oxo-6,8-dichloro-2H-1, 4-benzothiazine-1,1-dioxides (1-2a-b) and -1-oxides (3-4a-b) bioisosters of RPR 104632 in which the 3-carboxylic group was replaced by a carbonyl group were synthesized. Comparative in vitro pharmacological studies on this series of RPR 104632 analogs were performed using receptor binding assays. None of these compounds showed detectable binding affinity for the glycine-NMDA receptor.

  DOI：

  10.1016/s0014-827x(98)00097-4
• 作为产物：
  描述：

  2-amino-4,6-dichlorothiophenol 在 sodium hydroxide 、 水 、 双氧水 作用下， 以 氯仿 为溶剂， 反应 0.5h， 生成 Bis(2-amino-4,6-dichlorophenyl)disulfide
  参考文献：
  名称：

  Synthesis of 2-substituted-6,8-dichloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-1,1-dioxides and -1-oxides as glycine-NMDA receptor antagonists

  摘要：

  A number of 2-substituted-3,4-dihydro-3-oxo-6,8-dichloro-2H-1, 4-benzothiazine-1,1-dioxides (1-2a-b) and -1-oxides (3-4a-b) bioisosters of RPR 104632 in which the 3-carboxylic group was replaced by a carbonyl group were synthesized. Comparative in vitro pharmacological studies on this series of RPR 104632 analogs were performed using receptor binding assays. None of these compounds showed detectable binding affinity for the glycine-NMDA receptor.

  DOI：

  10.1016/s0014-827x(98)00097-4