3-amino-2-methylbenzophenone | 62261-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-2-methylbenzophenone
• 英文别名: Methanone, (3-amino-2-methylphenyl)phenyl-；(3-amino-2-methylphenyl)-phenylmethanone
• CAS: 62261-43-2
• 化学式: C₁₄H₁₃NO
• 分子量: 211.263
• InChiKey: NHTALIXIQROOBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-amino-2-methylbenzophenone 在 硫酸 、 水 、 potassium carbonate 、 copper(II) sulfate 、 sodium nitrite 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.5h， 生成 ethyl 2-(3-benzoyl-2-methylphenoxy)propanoate
  参考文献：
  名称：

  Astoin; Lepage; Fromantin, European Journal of Medicinal Chemistry, 1980, vol. 15, # 5, p. 457 - 462

  摘要：

  DOI：
• 作为产物：
  描述：

  2-methyl-3-nitro-benzophenone 在 stannous chloride 作用下， 以 盐酸 为溶剂， 生成 3-amino-2-methylbenzophenone
  参考文献：
  名称：

  Therapeutically useful N-phenylaniline derivatives

  摘要：

  提供了一般式为##STR1##的化合物，其中Ar代表未取代或取代为卤素原子或较低烷基的苯基，或代表噻吩基，R.sub.1代表氢或卤素原子或当Ar--CO--基团与氮原子的间位相对时，代表较低烷基，R.sub.2代表氢原子，或较低烷基或酰基基团，R.sub.3代表氢原子，较低烷基或苯基和其生理上可接受的盐。一般式I的化合物及其盐具有治疗功效，特别是作为镇痛剂。

  公开号：

  US04223039A1

文献信息

• Therapeutically useful N-phenylaniline derivatives
  申请人：Metabio Joullie

  公开号：US04223039A1

  公开（公告）日：1980-09-16

  There are provided compounds of the general formula ##STR1## in which Ar represents a phenyl group which is unsubstituted or substituted by a halogen atom or a lower alkyl group, or represents a thienyl group, R.sub.1 represents a hydrogen or halogen atom or, when the Ar--CO-- grouping is in the meta-position with respect to the nitrogen atom, a lower alkyl group, R.sub.2 represents a hydrogen atom, or a lower alkyl or an acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl or a phenyl group and a physiologically acceptable salt thereof. The compounds of the general formula I and their salts have therapeutic utility, especially as analgesics.

  提供了一般式为##STR1##的化合物，其中Ar代表未取代或取代为卤素原子或较低烷基的苯基，或代表噻吩基，R.sub.1代表氢或卤素原子或当Ar--CO--基团与氮原子的间位相对时，代表较低烷基，R.sub.2代表氢原子，或较低烷基或酰基基团，R.sub.3代表氢原子，较低烷基或苯基和其生理上可接受的盐。一般式I的化合物及其盐具有治疗功效，特别是作为镇痛剂。
• ASTOIN J.; LEPAGE F.; FROMANTIN J.-P.; POISSON M., EUR. J. MED. CHEM.-CHIM. THER., 1980, 15, NO 5, 457-462
  作者：ASTOIN J.、 LEPAGE F.、 FROMANTIN J.-P.、 POISSON M.

  DOI：——

  日期：——
• US4223039A
  申请人：——

  公开号：US4223039A

  公开（公告）日：1980-09-16
• Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides
  作者：John J. Parlow、Deborah A. Mischke、Scott S. Woodard

  DOI：10.1021/jo970571i

  日期：1997.8.1

  The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.
• Astoin; Lepage; Fromantin, European Journal of Medicinal Chemistry, 1980, vol. 15, # 5, p. 457 - 462
  作者：Astoin、Lepage、Fromantin

  DOI：——

  日期：——