N4,N4'-bis[(1R,2R)-2-(4-methylphenylsulfonamido)cyclohexyl]biphenyl-4,4'-disulfonamide | 1268855-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N4,N4'-bis[(1R,2R)-2-(4-methylphenylsulfonamido)cyclohexyl]biphenyl-4,4'-disulfonamide
• 英文别名: 4-methyl-N-[(1R,2R)-2-[[4-[4-[[(1R,2R)-2-[(4-methylphenyl)sulfonylamino]cyclohexyl]sulfamoyl]phenyl]phenyl]sulfonylamino]cyclohexyl]benzenesulfonamide
• CAS: 1268855-68-0
• 化学式: C₃₈H₄₆N₄O₈S₄
• 分子量: 815.069
• InChiKey: BIDPCMFHLUASAY-SIMZDOAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  54
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  218
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  4,4'-联苯二磺酰氯 、 (1R,2R)-(-)-N-对甲苯磺酰基-1,2-环己二胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以79%的产率得到N4,N4'-bis[(1R,2R)-2-(4-methylphenylsulfonamido)cyclohexyl]biphenyl-4,4'-disulfonamide
  参考文献：
  名称：

  Asymmetric addition of diethylzinc to benzaldehyde catalyzed by novel chiral C2-symmetric tetrakis(sulfonamide)–titanium(IV) complexes

  摘要：

  A series of chiral C-2-symmetric tetrakis(sulfonamides) 3a-f, 4a-f were prepared and employed as ligands for titanium(IV) complexes in the asymmetric addition of diethylzinc to benzaldehyde. The chiral secondary alcohols were obtained in high yields and in moderate enantioselectivities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.11.023

文献信息

• Asymmetric addition of diethylzinc to benzaldehyde catalyzed by novel chiral C2-symmetric tetrakis(sulfonamide)–titanium(IV) complexes
  作者：Antonio Venegas、Lucrecia Rivas、Gabriela Huelgas、Cecilia Anaya de Parrodi、Domingo Madrigal、Gerardo Aguirre、Miguel Parra-Hake、Daniel Chávez、Ratnasamy Somanathan

  DOI：10.1016/j.tetasy.2010.11.023

  日期：2010.12

  A series of chiral C-2-symmetric tetrakis(sulfonamides) 3a-f, 4a-f were prepared and employed as ligands for titanium(IV) complexes in the asymmetric addition of diethylzinc to benzaldehyde. The chiral secondary alcohols were obtained in high yields and in moderate enantioselectivities. (C) 2010 Elsevier Ltd. All rights reserved.