N-ethoxythiocarbonyl-4-hydroxy-benzylamine | 198898-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-ethoxythiocarbonyl-4-hydroxy-benzylamine
• 英文别名: O-ethyl N-[(4-hydroxyphenyl)methyl]carbamothioate
• CAS: 198898-38-3
• 化学式: C₁₀H₁₃NO₂S
• 分子量: 211.285
• InChiKey: NKRUVWCNANAKCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-ethoxythiocarbonyl-4-hydroxy-benzylamine 在 甲醇 、 三氟化硼乙醚 、 sodium methylate 作用下， 以 二氯甲烷 为溶剂， 反应 2.75h， 生成 O-乙基[[4-(3,4,5-三羟基-6-甲基四氢吡喃-2-基)氧基苯基]甲基氨基]硫代甲酸酯
  参考文献：
  名称：

  Synthesis of active principles from the leaves of Moringa oleifera using S-pent-4-enyl thioglycosides

  摘要：

  alpha-L-Rhamnosides of 4-hydroxy-benzyl compounds with nitrile, carbamate, and thiocarbamate groups occurring in Moringa oleifera leaf extracts and the alpha-L-rhamnoside of anisaldehyde derivatives were synthesised. Electrophilic activation of S-pent-4-enyl thiorhamnosides was applied for the construction of glycosidic linkages. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(98)00223-7
• 作为产物：
  描述：

  4-(烯丙氧基)苯甲腈 在 palladium diacetate 、 lithium aluminium tetrahydride 、 甲酸 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 57.17h， 生成 N-ethoxythiocarbonyl-4-hydroxy-benzylamine
  参考文献：
  名称：

  Synthesis of active principles from the leaves of Moringa oleifera using S-pent-4-enyl thioglycosides

  摘要：

  alpha-L-Rhamnosides of 4-hydroxy-benzyl compounds with nitrile, carbamate, and thiocarbamate groups occurring in Moringa oleifera leaf extracts and the alpha-L-rhamnoside of anisaldehyde derivatives were synthesised. Electrophilic activation of S-pent-4-enyl thiorhamnosides was applied for the construction of glycosidic linkages. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(98)00223-7

文献信息

• Synthesis of active principles from the leaves of Moringa oleifera using S-pent-4-enyl thioglycosides
  作者：Michael Leuck、Horst Kunz

  DOI：10.1016/s0008-6215(98)00223-7

  日期：1998.11

  alpha-L-Rhamnosides of 4-hydroxy-benzyl compounds with nitrile, carbamate, and thiocarbamate groups occurring in Moringa oleifera leaf extracts and the alpha-L-rhamnoside of anisaldehyde derivatives were synthesised. Electrophilic activation of S-pent-4-enyl thiorhamnosides was applied for the construction of glycosidic linkages. (C) 1998 Elsevier Science Ltd. All rights reserved.