N-(3-phenylpropyl)propanamide | 67191-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-phenylpropyl)propanamide
• CAS: 67191-50-8
• 化学式: C₁₂H₁₇NO
• mdl: MFCD01354035
• 分子量: 191.273
• InChiKey: AMHHACRZBSECQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-苯基-1-丙胺 、 乙基溴化镁 在 氯甲酸苄酯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 25.92h， 以92%的产率得到N-(3-phenylpropyl)propanamide
  参考文献：
  名称：

  Amidation through carbamates

  摘要：

  N-Alkyl carbamates of primary amines are easily converted into amides under treatment with Grignard reagents. Consequently, primary amines call be converted into amides in a one-pot reaction through carbamate protection and Grignard addition. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.113

文献信息

• GLUTAMATE AGGRECANASE INHIBITORS
  申请人：Sum Phaik-Eng

  公开号：US20100010012A1

  公开（公告）日：2010-01-14

  The present invention relates to modulators of metalloproteinase activity.

  本发明涉及金属蛋白酶活性调节剂。
• COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
  申请人：Bartolozzi Alessandra

  公开号：US20120316173A1

  公开（公告）日：2012-12-13

  Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  公式（I）的化合物已被揭示。本发明的化合物与CB2受体结合，并且是激动剂、拮抗剂或反向激动剂，可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• ALPHA HELIX MIMETIC COMPOSITIONS FOR TREATING CANCER AND OTHER CBP/CATENIN-MEDIATED DISEASES AND CONDITIONS
  申请人：PRISM BioLab Corporation

  公开号：US20140221657A1

  公开（公告）日：2014-08-07

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  本发明公开了代表公式（I）的α-螺旋类似物结构和化合物，其中一般公式和每个符号的定义如规范中所定义，涉及该化合物的方法以及涉及该方法的应用，用于治疗医学疾病，例如癌症疾病，纤维化疾病，以及包含类似物的制药组合物。
• THERMAL TRANSFER DONOR SHEET
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP3339045A1

  公开（公告）日：2018-06-27

  In a thermal transfer recording sheet including a base material and a colorant layer, the colorant layer includes a yellow dye layer containing a yellow dye, a magenta dye layer containing a magenta dye, and a cyan dye layer containing a cyan dye, and the cyan dye includes a compound represented by Formula (1a) or Formula (1b): where R1 to R7 are substituents, X- is an anion, and the compound of Formula (1b) has at least one anionic substituent.

  在包括基底材料和着色剂层的热转印记录纸中，着色剂层包括含有黄色染料的黄色染料层、含有品红色染料的品红色染料层和含有青色染料的青色染料层，青色染料包括由式（1a）或式（1b）表示的化合物： 其中 R1 至 R7 为取代基，X- 为阴离子，且式（1b）化合物具有至少一个阴离子取代基。
• Aryl dihydropyridinones and piperidinone MGAT2 inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10369140B2

  公开（公告）日：2019-08-06

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.

  本发明提供了式 (I) 的化合物： 或其立体异构体，或其药学上可接受的盐，其中所有变量如本文所定义。这些化合物是单酰基甘油酰基转移酶 2 型（MGAT2）抑制剂，可用作药物。