N⁴-benzyl-N⁶,N⁶-dimethyl-1(2)H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine | 106378-96-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: N⁴-benzyl-N⁶,N⁶-dimethyl-1(2)H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine
• 英文别名: N⁴-Benzyl-N⁶,N⁶-dimethyl-1(2)H-pyrazolo[3,4-d]pyrimidin-4,6-diyldiamin；4-N-benzyl-6-N,6-N-dimethyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
• CAS: 106378-96-5
• 化学式: C₁₄H₁₆N₆
• 分子量: 268.321
• InChiKey: GQANHDBWSRSSKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  69.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N⁴-benzyl-N⁶,N⁶-dimethyl-1(2)H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine 、 1-乙酰基-三-苄氧基-罗伯糖 在 四氯化锡 作用下， 以 乙腈 为溶剂， 反应 0.25h， 以43%的产率得到1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-4-benzylamino-6-dimethylamino-1H-pyrazolo[3,4-d]pyrimidine
  参考文献：
  名称：

  Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity

  摘要：

  A series of 1H-pyrazolo[3,4-d]pyrimidines (3-6) substituted at positions 1 (R-1 = Ph, H, tert-butyl and ribosetribenzoate), 4 (R-2 = chlorine, nitrogen and oxygen nucleophiles), and 6 (dimethylamino) have been synthesized and their effect on the release of histamine from rat peritoneal mast cells measured. After chemical stimulation, (polymer 48/80), several compounds (i.e. 3b, 4a, 4b, 4d, 4g, 5a), produce inhibition two to three times higher (40-60%) than DSCG but this action is lower after preincubation. 4b (R-1 = Ph, R-2 = NHCH2Ph; 50-70% inhibition) and 5a (R-1 = H, R-2 = OMe, 50-55% inhibition) are the most active ones in both experiments. With ovoalbumin as stimulus, several pyrazolopyrimidines show inhibition similar to DSCG, the most active compounds being 6a-d (IC50 = 12-16 muM; R-1 = ribosetribenzoate, R-2 = methoxy and amino), Compounds 4e (R-1 = t-butyl, R-2 = OMe) and 4g (R-1 = t-butyl, R-2 = piperidino) are inducers of the release of histamine (60 and 150% increase). Compounds 4b and 4e showed cytotoxic activity (IC50 =1 mug/ml) to HT-29 human colon cancer cells. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01225-9
• 作为产物：
  描述：

  1-tert-butyl-4-chloro-6-dimethylamino-1H-pyrazolo[3,4-d]pyrimidine 在 甲酸 作用下， 以 四氢呋喃 为溶剂， 生成 N⁴-benzyl-N⁶,N⁶-dimethyl-1(2)H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine
  参考文献：
  名称：

  Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity

  摘要：

  A series of 1H-pyrazolo[3,4-d]pyrimidines (3-6) substituted at positions 1 (R-1 = Ph, H, tert-butyl and ribosetribenzoate), 4 (R-2 = chlorine, nitrogen and oxygen nucleophiles), and 6 (dimethylamino) have been synthesized and their effect on the release of histamine from rat peritoneal mast cells measured. After chemical stimulation, (polymer 48/80), several compounds (i.e. 3b, 4a, 4b, 4d, 4g, 5a), produce inhibition two to three times higher (40-60%) than DSCG but this action is lower after preincubation. 4b (R-1 = Ph, R-2 = NHCH2Ph; 50-70% inhibition) and 5a (R-1 = H, R-2 = OMe, 50-55% inhibition) are the most active ones in both experiments. With ovoalbumin as stimulus, several pyrazolopyrimidines show inhibition similar to DSCG, the most active compounds being 6a-d (IC50 = 12-16 muM; R-1 = ribosetribenzoate, R-2 = methoxy and amino), Compounds 4e (R-1 = t-butyl, R-2 = OMe) and 4g (R-1 = t-butyl, R-2 = piperidino) are inducers of the release of histamine (60 and 150% increase). Compounds 4b and 4e showed cytotoxic activity (IC50 =1 mug/ml) to HT-29 human colon cancer cells. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01225-9

文献信息

• Robins, Journal of the American Chemical Society, 1957, vol. 79, p. 6407,6412
  作者：Robins

  DOI：——

  日期：——
• Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity
  作者：J Quintela

  DOI：10.1016/s0223-5234(01)01225-9

  日期：2001.4

  A series of 1H-pyrazolo[3,4-d]pyrimidines (3-6) substituted at positions 1 (R-1 = Ph, H, tert-butyl and ribosetribenzoate), 4 (R-2 = chlorine, nitrogen and oxygen nucleophiles), and 6 (dimethylamino) have been synthesized and their effect on the release of histamine from rat peritoneal mast cells measured. After chemical stimulation, (polymer 48/80), several compounds (i.e. 3b, 4a, 4b, 4d, 4g, 5a), produce inhibition two to three times higher (40-60%) than DSCG but this action is lower after preincubation. 4b (R-1 = Ph, R-2 = NHCH2Ph; 50-70% inhibition) and 5a (R-1 = H, R-2 = OMe, 50-55% inhibition) are the most active ones in both experiments. With ovoalbumin as stimulus, several pyrazolopyrimidines show inhibition similar to DSCG, the most active compounds being 6a-d (IC50 = 12-16 muM; R-1 = ribosetribenzoate, R-2 = methoxy and amino), Compounds 4e (R-1 = t-butyl, R-2 = OMe) and 4g (R-1 = t-butyl, R-2 = piperidino) are inducers of the release of histamine (60 and 150% increase). Compounds 4b and 4e showed cytotoxic activity (IC50 =1 mug/ml) to HT-29 human colon cancer cells. (C) 2001 Editions scientifiques et medicales Elsevier SAS.