The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
本公开提供了用于抑制Delta-5 Desaturase ("D5D")的化合物。这些化合物具有一般的
化学式(I),其中
化学式(I)中的变量在此处被定义。本公开还提供了包括这些化合物的药物组合物,这些化合物的用途,以及用于治疗代谢或心血管疾病的组合物。此外,本公开提供了在合成化合物的中间体中有用的中间体。