N-(4-Ethenylphenyl)-N-(phenylmethyl)benzenemethanamine | 20349-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Ethenylphenyl)-N-(phenylmethyl)benzenemethanamine
• 英文别名: N,N-dibenzyl-4-ethenylaniline
• CAS: 20349-54-6
• 化学式: C₂₂H₂₁N
• 分子量: 299.415
• InChiKey: DSESNMUBMUWYIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(4-Ethenylphenyl)-N-(phenylmethyl)benzenemethanamine 、 diethyl 2-benzyl-2-bromomalonate 在 copper(l) iodide 、 五甲基二乙烯三胺 、 四丁基溴化铵 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以79%的产率得到
  参考文献：
  名称：

  An Efficient Generation of a Functionalized Tertiary-Alkyl Radical for Copper-catalyzed Tertiary-Alkylative Mizoroki-Heck type Reaction

  摘要：

  alpha-Halocarbonyl compounds undergo beta-hydrogen elimination to give conjugated olefins in the presence of a transition-metal catalyst. However, a copper/triamine catalyst system can induce the alkylative Mizoroki-Heck reaction of styrenes with tertiary-alkyl halides possessing a withdrawing group under very mild conditions. This reaction provides an efficient synthetic methodology for tertiary-alkylated styrenes.

  DOI：

  10.1021/ja409661n

文献信息

• Radical and Cation Crossover Reaction System Enables Synthesis of Complex Aliphatic Chains Possessing Functionalized Quaternary Carbons
  作者：Yumi Murata、Taisei Shimada、Takashi Nishikata

  DOI：10.1246/bcsj.20190120

  日期：2019.9.15

  Controlling the reactive species during the synthesis of complex aliphatic chains containing a quaternary carbon is incredibly difficult. In this paper, we efficiently controlled both radical and c...

  在含有季碳的复杂脂肪链的合成过程中控制反应性物质是非常困难的。在本文中，我们有效地控制了自由基和...
• US5080989A
  申请人：——

  公开号：US5080989A

  公开（公告）日：1992-01-14
• An Efficient Generation of a Functionalized Tertiary-Alkyl Radical for Copper-catalyzed Tertiary-Alkylative Mizoroki-Heck type Reaction
  作者：Takashi Nishikata、Yushi Noda、Ryo Fujimoto、Tomomi Sakashita

  DOI：10.1021/ja409661n

  日期：2013.11.6

  alpha-Halocarbonyl compounds undergo beta-hydrogen elimination to give conjugated olefins in the presence of a transition-metal catalyst. However, a copper/triamine catalyst system can induce the alkylative Mizoroki-Heck reaction of styrenes with tertiary-alkyl halides possessing a withdrawing group under very mild conditions. This reaction provides an efficient synthetic methodology for tertiary-alkylated styrenes.