Methyl 2-[[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]-methylamino]acetate | 1593111-63-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-[[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]-methylamino]acetate
• 英文别名: methyl 2-[[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]-methylamino]acetate
• CAS: 1593111-63-7
• 化学式: C₁₂H₁₆N₄O₅S
• 分子量: 328.349
• InChiKey: NKLKKHAHSKACAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  甲醇 、 N-[7-(N,N-二甲胺基)-4-苯并呋吖基]二甲氨乙酰基氯化铵 反应 1.0h， 以97%的产率得到Methyl 2-[[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]-methylamino]acetate
  参考文献：
  名称：

  Fluorescent analog of OSW-1 and its cellular localization

  摘要：

  OSW-1 is a steroidal saponin, which has emerged as an attractive anticancer agent with highly cancer cell selective activity. A fluorescent analog was prepared from the natural product to analyze its cellular uptake and localization. We found that the fluorescent analog is rapidly internalized into cells and is primarily distributed in endoplasmic reticulum and Golgi apparatus. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.009

文献信息

• Fluorescent analog of OSW-1 and its cellular localization
  作者：Rika Yamada、Tomoya Takeshita、Masato Hiraizumi、Daisuke Shinohe、Yoshihiro Ohta、Kaori Sakurai

  DOI：10.1016/j.bmcl.2014.02.009

  日期：2014.4

  OSW-1 is a steroidal saponin, which has emerged as an attractive anticancer agent with highly cancer cell selective activity. A fluorescent analog was prepared from the natural product to analyze its cellular uptake and localization. We found that the fluorescent analog is rapidly internalized into cells and is primarily distributed in endoplasmic reticulum and Golgi apparatus. (C) 2014 Elsevier Ltd. All rights reserved.