1,1,4,4-四(4-氯苯基)-1,3-丁二烯 | 57710-75-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,1,4,4-四(4-氯苯基)-1,3-丁二烯
• 英文名称: 1,1,4,4-Tetrakis(4-chlorophenyl)-1,3-butadiene
• 英文别名: 1-Chloro-4-[1,4,4-tris(4-chlorophenyl)buta-1,3-dienyl]benzene
• CAS: 57710-75-5
• 化学式: C₂₈H₁₈Cl₄
• 分子量: 496.263
• InChiKey: WYSHRVTTYKVCSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,1,4,4-四(4-氯苯基)-1,3-丁二烯 在 三(三氟乙酸)碘 作用下， 以 四氯化碳 为溶剂， 反应 3.0h， 以23%的产率得到1,2,4,4-tetrakis(4-chlorophenyl)-3-buten-1-one
  参考文献：
  名称：

  Reactions of Alkenes with Iodine(III) Tris(trifluoroacetate)

  摘要：

  1- 芳基烯、1,1- 二芳基烯和 1,1- 二芳基丙烯与碘（III）三（三氟乙酸盐）反应生成 1,2- 二芳基-1-烷酮、1-芳基-2-（4-碘苯基）-1-烷酮、安息香、苯并芘和碘乙烯。1,1,4,4-四芳基-1,3-丁二烯的类似反应生成 1,2,4,4-四芳基-3-丁烯-1-酮。1,1,5,5-四芳基-1,4-戊二烯和 1,1,6,6-四芳基-1,5-己二烯的反应也生成了二羰基化合物。该反应涉及芳基迁移。本文讨论了该反应的机理和在有机合成中的用途。

  DOI：

  10.1246/bcsj.62.3182
• 作为产物：
  描述：

  1-氯-4-[1-(4-氯苯基)乙烯基]苯 在 溴 作用下， 生成 1,1,4,4-四(4-氯苯基)-1,3-丁二烯
  参考文献：
  名称：

  Tadros, Journal of the Chemical Society, 1954, p. 2966

  摘要：

  DOI：

文献信息

• Manganese(III) or Cobalt(III)-Mediated Oxidative Radical Reactions of Terminal Dienes. One-Pot Synthesis of Bis(dihydrofuran)s
  作者：Hiroshi Nishino、Tomoaki Yoshida、Kazu Kurosawa

  DOI：10.1246/bcsj.64.1097

  日期：1991.4

  5-hexadienes with tris(2,4-pentanedionato)-manganese(III) ([Mn(acac)3]) gave α,ω-bis(dihydrofuryl)alkanes (abbreviated bis(dihydrofuran)s, hereafter) in good yields. The reactions with tris(2,4-pentanedionato)cobalt(III) ([Co(acac)3]) instead of [Mn(acac)3] yielded the same bis(dihydrofuran)s quantitatively. The dienes also reacted with ethyl 3-oxobutanoate in the presence of manganese(III) acetate ([Mn(OAc)3])

  末端二烯如 1,4-戊二烯和 1,5-己二烯与三(2,4-戊二酮)-锰(III) ([Mn(acac)3]) 反应生成α,ω-双(二氢呋喃基)烷烃（缩写为双（二氢呋喃），下文中）收率良好。与三(2,4-戊二酮)钴(III) ([Co(acac)3]) 代替[Mn(acac)3] 的反应定量产生了相同的双(二氢呋喃)。在乙酸锰 (III) ([Mn(OAc)3]) 或乙酸钴 (III) ([Co(OAc)3]) 存在下，二烯还与 3-氧代丁酸乙酯反应生成相应的双（二氢呋喃） s。1,3-丁二烯与锰(III)或钴(III)配合物的反应仅提供一(二氢呋喃)和氧化重排产物，但未形成相应的双(二氢呋喃)。反应 1, 在 [Mn(OAc)3] 存在下，5-己二烯与丙二酸氢乙酯并没有得到双环化产物，而是以中等产率得到单（γ-内酯）。双(二氢呋喃)形成的合成应用及局限性...
• Novel reactions of 1,1,4,4-tetraaryl-1,2,3-butatrienes with elemental sulfur and selenium
  作者：Norihiro Tokitoh、Hiroshi Hayakawa、Midori Goto、Wataru Ando

  DOI：10.1016/s0040-4039(00)82083-3

  日期：1988.1

  Sulfurization and selenation reactions of 1,1,4,4-tetraaryl-1,2,3-butatrienes were examined to give novel 1,2,3,4,5-pentathiepane and 1,2,5-triselenepane ring systems. Further degradation of these new heterocycles using DBU/DMF was also described.

  研究了1,1,4,4-四芳基-1,2,3-丁烯的硫化和硒化反应，得到了新的1,2,3,4,5-戊硫戊二烯和1,2,5-三硒烯戊环体系。还描述了使用DBU / DMF对这些新杂环的进一步降解。
• Brand; Horn; Bausch, Journal fur praktische Chemie (Leipzig 1954), 1930, vol. <2> 127, p. 240,242
  作者：Brand、Horn、Bausch

  DOI：——

  日期：——
• In vitro antimicrobial susceptibilities of three Porphyromonas spp and in vivo responses in the oral cavity of cats to selected antimicrobial agents
  作者：JM NORRIS、DN LOVE

  DOI：10.1111/j.1751-0813.2000.tb11895.x

  日期：2000.8

  ObjectivesTo determine in vitro susceptibility ofPorphyromonas gingivalis, P salivosaandP circumdentariato seven antimicrobial agents by agar dilution and Epsilometer test methods and to assess the effectiveness of these antimicrobial agents in reducing the numbers of eachPorphyromonasspp in the oral cavity of 16 domestic cats.DesignA two‐part prospective study involving in vitro antimicro‐bial studies usingPorphyromonasspp obtained from naturally occurring feline infections and in vivo antimicrobial response studies using client‐owned cats with naturally occurring periodontal disease.ProcedureIsolates (n = 25) of three felinePorphyromonasspp from the oral cavity and oral‐associated disease were tested for their in vitro susceptibility to amoxycillin, amoxycillin‐clavulanate, benzylpenicillin, clindamycin, doxycycline, erythromycin and metronidazole, using agar dilution and Epsilometer test methods. Digoxigenin‐labelled whole chromosomal DNA probes directed againstP gingivalis VPB3492,P circumdentariaNCTC 12469TandP salivosaVPB 3313 were used to quantify organisms taken from two sample sites at the gingival margins of these cats prior to, and 5 days after, treatment with one of four commonly used antimicrobial products (amoxycillin‐clavulanate, clindamycin, doxycycline or spiramycin‐metronidazole). The response to treatment was assessed clinically for each cat.ResultsAll isolates were susceptible in vitro to all seven antimicrobial agents using both methods. The numbers ofP gingivaliswere not reduced at the gingival sample sites by administration of amoxycillin‐clavulanate for 5 days, although this treatment reduced the numbers ofP salivosaandP circumdentaria tobelow detection levels in six of eight and two of three of sample sites, respectively; clinical improvement was not observed in cats treated with amoxycillin‐clavulanate. Treatment with clindamycin, doxycycline or spiramycin‐metronidazole resulted in clinical improvement and a marked reduction of allPorphyromonasisolates at the sample sites.ConclusionThe Epsilometer test is a simple and accurate method for determining the minimum inhibitory concentration forP gingivalis, P salivosaandP circumdentaria.All strains were susceptible in vitro to all the antimicrobial agents tested, although clinical improvement of gingival disease was not noted with amoxycillin‐clavulanate when given for 5 days at usual doses. This appears to be the first report of the disparity between the in vivo and in vitro susceptibility of oral bacterial strains to amoxycillin‐clavulanate in the veterinary dental literature. This also appears to be the first report in which clinical and microbiological responses to commonly used antimicrobial agents for periodontal disease in cats has been documented and quantified. It was shown that treatment with clindamycin, spiramycin‐metronidazole or doxycycline not only produced a substantial reduction in the number ofPorphyromonasspp (in the majority of cases to below detection levels), but also resulted in substantial clinical improvement. This would indicate that these antimicrobial agents are useful adjunctive therapy to mechanical debridement in domestic cats.
• FUTAMI, YASUO;NISHINO, HIROSHI;KUROSAWA, KAZU, BULL. CHEM. SOC. JAP., 62,(1989) N0, C. 3182-3186
  作者：FUTAMI, YASUO、NISHINO, HIROSHI、KUROSAWA, KAZU

  DOI：——

  日期：——