4-deuterio-N-methylpyridine-3-carboxamide | 1021463-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-deuterio-N-methylpyridine-3-carboxamide
• CAS: 1021463-87-5
• 化学式: C₇H₈N₂O
• 分子量: 137.145
• InChiKey: ZYVXHFWBYUDDBM-WFVSFCRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基烟酰胺 在 重水 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以82%的产率得到4-deuterio-N-methylpyridine-3-carboxamide
  参考文献：
  名称：

  Deprotonation of pyridine carboxamides using lithium magnesiates bases

  摘要：

  Regioselective deprotonation of N-methyl- and tert-butylpyridine carboxamides using lithium magnesiates bases was achieved at room temperature avoiding nucleophilic addition on the pyridine molecule and auto-condensation of the arylmetal intermediates on the amide group was described. The hydrogen-magnesium exchange was evidenced using H-1 NMR spectroscopy at room temperature and the reactivity of the lithium 2- 3- and 4-carboxamidopyridinylmagnesiates complexes towards electrophiles and in cross-coupling reactions was studied. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.064

文献信息

• Deprotonation of pyridine carboxamides using lithium magnesiates bases
  作者：Haçan Hawad、Omar Bayh、Christophe Hoarau、Francois Trécourt、Guy Quéguiner、Francis Marsais

  DOI：10.1016/j.tet.2008.01.064

  日期：2008.3

  Regioselective deprotonation of N-methyl- and tert-butylpyridine carboxamides using lithium magnesiates bases was achieved at room temperature avoiding nucleophilic addition on the pyridine molecule and auto-condensation of the arylmetal intermediates on the amide group was described. The hydrogen-magnesium exchange was evidenced using H-1 NMR spectroscopy at room temperature and the reactivity of the lithium 2- 3- and 4-carboxamidopyridinylmagnesiates complexes towards electrophiles and in cross-coupling reactions was studied. (c) 2008 Elsevier Ltd. All rights reserved.