N-acryloyl-5-ethoxy pyrrolidine | 107979-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-acryloyl-5-ethoxy pyrrolidine
• 英文别名: 1-(2-ethoxypyrrolidin-1-yl)prop-2-en-1-one
• CAS: 107979-15-7
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: OYLUJUXXWXZCNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-acryloyl-5-ethoxy pyrrolidine 在 盐酸 、 三乙胺 、 zinc(II) chloride 作用下， 以 丙酮 、 甲苯 、 乙腈 为溶剂， 反应 10.0h， 生成 (8S,8aR)-5-Trimethylsilanyloxy-1,2,3,7,8,8a-hexahydro-indolizine-8-carboxylic acid ethyl ester
  参考文献：
  名称：

  Ihara, Masataka; Kirihara, Tomoko; Fukumoto, Keiichiro, Heterocycles, 1985, vol. 23, # 5, p. 1097 - 1100

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4,4-diethoxybutyl)prop-2-enamide 以77%的产率得到
  参考文献：
  名称：

  PINSCHMIDT, ROBERT K. (JR);DIXON, DALE D.;BURGOYNE, WILLIAM F. (JR)

  摘要：

  DOI：

文献信息

• Stereocontrolled construction of octahydroquinolizines, octahydroindolizines, hexahydrobenzo[a]quinolizines, and an octahydroindolo[2,3-a]quinolizine by an intramolecular double Michael reaction: synthesis of (±)epilupinine
  作者：Masataka Ihara、Tomoko Kirihara、Akihiro Kawaguchi、Mayumi Tsuruta、Keiichiro Fukumoto、Tetsuji Kametani

  DOI：10.1039/p19870001719

  日期：——

  trifluoromethanesulphonate in the presence of triethylamine at –78 to 20 °C. A simple synthesis of an alkaloid, (±)-epilupinine, was accomplished. Hexahydrobenzo[a]-quinolizin-4-ones and an octahydroindolo[2,3-a]quinolizin-4-one were also constructed by the same method.

  在两种不同条件下，从α，β-不饱和烯酰胺酯中立体控制一步合成八氢喹啉嗪和八氢吲哚嗪衍生物。在180-185°C下，在三甲基氯硅烷，三乙胺和氯化锌的存在下加热，在–78至20°C下，在三乙胺的存在下，用二甲基叔丁基甲硅烷基三氟甲磺酸酯处理。完成了生物碱（±）-癫痫素的简单合成。六氢苯并[一个]喹嗪-4-酮和八氢化吲哚并[2,3-一个〕喹嗪-4-酮也通过相同的方法构成。
• Polymers of self- and hydroxyl reactive formaldehyde-free cyclic
  申请人：Air Products and Chemicals, Inc.

  公开号：US04663410A1

  公开（公告）日：1987-05-05

  A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, or R and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, or R.sup.2 and R.sup.3 together are a C.sub.2 -C.sub.4 alkylene group, R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen. Under acidic conditions the above compounds in which R.sup.1 is hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula: ##STR2## The dialkyl acetal and ketal compounds and the cyclic hemiamidal and hemiamide ketal compounds can be homopolymerized or polymerized with other copolymerizable monomers.

  以下化合物的化学式：##STR1## 其中R是具有使氮原子电子不足的官能团的C.sub.3-C.sub.24烯烃不饱和有机基团，烯烃不饱和官能团是可聚合的，R.sup.1是氢或C.sub.1-C.sub.4烷基基团，或R和R.sup.1与氮原子一起可以形成具有使氮原子电子不足的烯烃不饱和5至7成员环，烯烃不饱和官能团是可聚合的，R.sup.2和R.sup.3是氢、C.sub.1-C.sub.4烷基或酰基基团，或R.sup.2和R.sup.3一起是C.sub.2-C.sub.4烷基撑链，R.sup.4是氢或C.sub.1-C.sub.4烷基、酰基、酯、酰胺或酸基团，n是1至10的整数，当R为(meth)acryloyl时，n不为1，R.sup.2和R.sup.3为甲基，R.sup.1和R.sup.4为氢。在酸性条件下，其中R.sup.1为氢的上述化合物会生成以下的环状半酰胺和半酰胺缩酮：##STR2## 双烷基缩醛和缩酮化合物以及环状半酰胺和半酰胺缩酮化合物可以与其他共聚单体进行均聚或共聚。
• Self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and
  申请人：Air Products and Chemicals, Inc.

  公开号：US04691026A1

  公开（公告）日：1987-09-01

  A compound represented by the following formula: ##STR1## wherein R is a C.sub.3 -C.sub.24 olefinically unsaturated organic radical having functionality which renders the nitrogen atom electron deficient, the olefinic unsaturation functionality being polymerizable, R.sup.1 is hydrogen or a C.sub.1 -C.sub.4 alkyl radical, or R and R.sup.1 together with the nitrogen atom can form an olefinically unsaturated 5 to 7-member ring which has functionality that renders the nitrogen atom electron deficient and the olefinic unsaturation functionality is polymerizable, R.sup.2 and R.sup.3 are hydrogen, a C.sub.1 -C.sub.4 alkyl or acyl radical, or R.sup.2 and R.sup.3 together are a C.sub.2 -C.sub.4 alkylene group, R.sup.4 is hydrogen or a C.sub.1 -C.sub.4 alkyl, acyl, ester, amide or acid group, and n is an integer from 1 to 10, provided n is not 1 when R is (meth)acryloyl, R.sup.2 and R.sup.3 are methyl and R.sup.1 and R.sup.4 are hydrogen. Under acidic conditions the above compounds having R.sup.1 =hydrogen afford cyclic hemiamidals and hemiamide ketals of the following formula ##STR2##

  以下是由以下公式表示的化合物：##STR1## 其中，R是具有使氮原子电子亏损的官能团的C.sub.3-C.sub.24烯烃不饱和有机基团，烯烃不饱和官能团具有可聚合性，R.sup.1是氢或C.sub.1-C.sub.4烷基基团，或者R和R.sup.1与氮原子一起可以形成具有使氮原子电子亏损的官能团的烯烃不饱和5到7元环，烯烃不饱和官能团具有可聚合性，R.sup.2和R.sup.3是氢、C.sub.1-C.sub.4烷基或酰基基团，或者R.sup.2和R.sup.3一起是C.sub.2-C.sub.4烷基基团，R.sup.4是氢或C.sub.1-C.sub.4烷基、酰基、酯、酰胺或酸基团，n是1到10的整数，当R为(meth)acryloyl，R.sup.2和R.sup.3为甲基，R.sup.1和R.sup.4为氢时，n不为1。在酸性条件下，具有R.sup.1=氢的上述化合物产生以下公式的环状半酰胺和半酰胺缩醛：##STR2##
• Nonwoven binder emulsions of vinyl acetate/ethylene copolymers having
  申请人：Air Products and Chemicals, Inc.

  公开号：US04698384A1

  公开（公告）日：1987-10-06

  A copolymer emulsion for bonding nonwoven products comprising an aqueous medium having colloidally dispersed therein a copolymer consisting essentially of vinyl acetate, 5-35 wt % ethylene and 2 to 10 wt % of an amide functional crosslinking comonomer which is N-methylolacrylamide or a compound of the formula R--NH--(CH.sub.2).sub.n --CH(OR').sub.2 where R is (meth)acryloyl, R' is a C.sub.1 -C.sub.4 alkyl group and n is 3 or 4, the copolymer emulsion prepared in the presence of 0.1 to 1 wt % polyvinyl pyrrolidone, based on vinyl acetate in the copolymer. Such emulsion binder copolymers demonstrate improved solvent resistance.

  一种共聚物乳液用于粘合非织造产品，包括具有胶体分散其中的水介质，共聚物本质上由醋酸乙烯，5-35重量％乙烯和2-10重量％酰胺功能交联共聚单体组成，该酰胺功能交联共聚单体为N-甲基丙烯酰胺或化合物R-NH-(CH.sub.2).sub.n-CH(OR').sub.2，其中R为(meth)acryloyl，R'为C.sub.1-C.sub.4烷基，n为3或4，该共聚物乳液在存在0.1-1重量％聚乙烯吡咯烷酮制备，基于共聚物中的醋酸乙烯。这种乳液粘合剂共聚物表现出改善的溶剂抵抗性。
• Nonwoven products bonded with binder emulsions of vinyl acetate/ethylene
  申请人：Air Products and Chemicals, Inc.

  公开号：US04745025A1

  公开（公告）日：1988-05-17

  A copolymer emulsion for bonding nonwoven products comprising an aqueous medium having colloidally dispersed therein a copolymer consisting essentially of vinyl acetate, 5-35 wt % ethylene and 2 to 10 wt % of an amide functional crosslinking comonomer which is N-methylolacrylamide or a compound of the formula R--NH--(CH.sub.2).sub.n --CH(OR').sub.2 where R is (meth)acryloyl, R' is a C.sub.1 -C.sub.4 alkyl group and n is 3 or 4, the copolymer emulsion prepared in the presence of 0.1 to 1 wt % polyvinyl pyrrolidone, based on vinyl acetate in the copolymer. Such emulsion binder copolymers demonstrate improved solvent resistance.

  一种共聚物乳液，用于粘合非织造产品，包括一种水性介质，在其中胶体分散着一种共聚物，该共聚物基本上由乙酸乙烯酯、5-35重量％的乙烯和2至10重量％的酰胺交联共聚单体组成，所述酰胺交联共聚单体为N-甲基丙烯酰胺或式R--NH--（CH.sub.2）.sub.n--CH（OR'）.sub.2的化合物，其中R为（甲）基丙烯酰基，R'为C.sub.1-C.sub.4烷基，n为3或4，该共聚物乳液在存在0.1至1重量％的聚乙烯吡咯烷酮（基于共聚物中的乙酸乙烯酯）的情况下制备。这种乳液粘合剂共聚物表现出改善的溶剂抗性。