1-Phenylacetyl-2-isopropyliden-hydrazin | 1080-09-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Phenylacetyl-2-isopropyliden-hydrazin
• 英文别名: 2-phenyl-N-(propan-2-ylideneamino)acetamide
• CAS: 1080-09-7
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.245
• InChiKey: VKUOBYZDDJZGSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Phenylacetyl-2-isopropyliden-hydrazin 在 palladium on activated charcoal 氢气 作用下， 生成 1-Phenylacetyl-2-isopropylhydrazin
  参考文献：
  名称：

  酰化肼芥末。

  摘要：

  DOI：

  10.1021/jo01277a023
• 作为产物：
  描述：

  苯乙酸肼 以77%的产率得到
  参考文献：
  名称：

  STEPHANIDOU-STEPHANATOU, J.;LEFKOPOULOU, S., J. HETEROCYCL. CHEM., 1982, 19, N 4, 705-711

  摘要：

  DOI：

文献信息

• Synthesis and Reactions of 2(5)-[Benzyl or Cyanomethyl]-1,3,4-oxadiazoles
  作者：M. M. Hamad

  DOI：10.1002/ardp.19903230908

  日期：——

  (10a, b), were synthesized. Also 5‐chloro‐2‐benzyl‐1,3,4‐oxadiazole 7 was prepared. Reaction of amines, hydrazines, and sodium azide with 7 gave the corresponding 2‐arylamino (8a, b), 5‐hydrazino or phenylhydrazino (8c, d) and 2‐azido derivatives 9, respectively. Mannich bases (11a, b) were prepared by the reaction of sec. amines with 9a. 5‐Carboxymethylthio‐1,3,4‐oxadiazoles (12a, b) and their ethyl

  一系列五元杂环，即5-（苄基或氰甲基）-3-乙酰基-2,2-二取代-1,3,4-恶二唑啉（3a-e），2,5-二取代-1,3,4 -恶二唑 (4a, b), 2-羟基-5- (苄基或氰甲基) -1,3,4-恶二唑 (5a, b), 1,2,5-三取代-1,3,4-三唑 (6a , b), 和 2- (苄基或氰基-甲基)-1,3,4-恶二唑-5-硫醇 (10a, b), 合成。因此制备了5-氯-2-苄基-1,3,4-恶二唑7。胺、肼和叠氮化钠与 7 反应分别得到相应的 2-芳基氨基 (8a, b)、5-肼或苯肼 (8c, d) 和 2-叠氮衍生物 9。曼尼希碱 (11a, b) 通过仲胺与 9a 的反应制备。5-羧甲硫基-1,3,4-恶二唑（12a，b）及其乙酯（13a，b）也被制备。
• Conformational behaviour and / isomerization of -acyl and -aroylhydrazones
  作者：Gerardo Palla、Giovanni Predieri、Paolo Domiano、Carlo Vignali、Walter Turner

  DOI：10.1016/s0040-4020(01)87332-4

  日期：1986.1

  The stereochemical behaviour of -acyl and -aroylhydrazones of aromatic aldehydes, of pyruvates and of acetone, in polar and less polar solvents, has been studied by HPLC and by NMR techniques. Geometrical isomers and / amide conformers have been found for -acylhydrazones, while for -aroylhydrazones only geometrical isomers were detected. Energy barriers of isomers are reported, and solvent effects

  已经通过HPLC和NMR技术研究了芳族醛，丙酮酸和丙酮的-酰基和-芳酰基hydr在极性和极性较小的溶剂中的立体化学行为。对于-酰基hydr，发现了几何异构体和/或酰胺构象异构体，而对于-芳酰基yl，仅发现了几何异构体。报告了异构体的能垒，并就氢键相互作用讨论了溶剂效应。
• Hypervalent iodine oxidation of N-acylhydrazones and N-phenylsemicarbazone: an efficient method for the synthesis of derivatives of 1,3,4-oxadiazoles and .DELTA.3-1,3,4-oxadiazolines
  作者：Ruiyang Yang、Lixin Dai

  DOI：10.1021/jo00064a027

  日期：1993.6

  The oxidation of ketone N-acylhydrazones 1 by phenyliodine(III) diacetate (PIDA) in alcohol gave 2-alkoxy-DELTA3-1,3,4-oxadiazolines 4 in excellent yields, while the oxidative cyclization of aldehyde N-acylhydrazone 2 by PIDA in methanolic sodium acetate gave 2,5-disubstituted 1,3,4-oxadiazoles in good yields. The oxidation of acetone 4-phenylsemicarbazone afforded 2-(N-phenylimino)-DELTA3-1,3,4-oxadiazoline in excellent yield.
• Stephanidou-Stephanatou, J.; Lefkopoulou, S., Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 705 - 711
  作者：Stephanidou-Stephanatou, J.、Lefkopoulou, S.

  DOI：——

  日期：——
• Yang Rui-Yang, Dai Li-Xin, J. Org. Chem., 58 (1993) N 12, S 3381-3383
  作者：Yang Rui-Yang, Dai Li-Xin

  DOI：——

  日期：——