3-Phenylcyclohexanecarboxylic Acid | 107203-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Phenylcyclohexanecarboxylic Acid
• 英文别名: 3-phenylcyclohexane-1-carboxylic acid
• CAS: 107203-07-6
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: IDLNNHCBDQYOAP-UHFFFAOYSA-N

物化性质

• 沸点：
  360.0±31.0 °C(Predicted)
• 密度：
  1.116±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-phenyl-1,2-cyclohexanedicarboxylic acid 在 Pt/titania 作用下， 以 水 、 乙腈 为溶剂， 以53%的产率得到3-Phenylcyclohexanecarboxylic Acid
  参考文献：
  名称：

  Selective photoelectrochemical oxidation of vicinal cyclohexanedicarboxylic acids: a mechanistic study

  摘要：

  DOI：

  10.1021/jo00288a035

文献信息

• Heat shock protein 70 (hsp-70) receptor ligands
  申请人：Duke University

  公开号：US10000469B2

  公开（公告）日：2018-06-19

  Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.

  诱导型 HSP70 在多种人类肿瘤中过度表达，其表达与肿瘤转移以及患者对放疗和化疗的不良反应有关。HSP70 小分子抑制剂的发现为癌症治疗提供了一种新疗法。HS72是一种苯并咪唑哌啶羧酰胺，已被确定为HSP70的异构抑制剂，并在体内显示出良好的肿瘤生长抑制作用。
• PROCESS FOR PRODUCING OXYGENIC COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1797953B1

  公开（公告）日：2011-01-05
• Liquid crystalline optical film, compensating film for liquid crystal display and liquid crystal display
  申请人：NIPPON OIL COMPANY, LIMITED

  公开号：EP0758013B1

  公开（公告）日：2000-10-11
• Method for Producing Oxygen-Containing Compound
  申请人：Hagiya Koji

  公开号：US20080064898A1

  公开（公告）日：2008-03-13

  An oxidation catalyst composition is obtained by mixing a selenium compound, a nitrogen-containing aromatic compound and an acid, and if necessary, in the presence of a solvent. The oxidation catalyst composition shows an oxidation catalyst activity in the oxidation reaction of an organic compound. For example, at least one oxygen-containing compound selected from an alcohol compound, an aldehyde compound, a ketone compound and a carboxylic acid compound is obtained by reacting the olefin compound having two or more hydrogen atoms on the carbon atom at α-position of a carbon-carbon double bond with an organic hydroperoxide compound in the presence of the oxidation catalyst composition.
• HEAT SHOCK PROTEIN 70 (HSP-70) RECEPTOR LIGANDS
  申请人：Duke University

  公开号：US20170174660A1

  公开（公告）日：2017-06-22

  Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.