2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one | 276879-69-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: 2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one
• 英文别名: 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one
• CAS: 276879-69-7
• 化学式: C₂₇H₂₃N₃O₃
• 分子量: 437.498
• InChiKey: SXLZGYJKTPZGBI-UHFFFAOYSA-N

物化性质

• 沸点：
  621.5±65.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.56
• 重原子数：
  33.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  80.14
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one 在 manganese(IV) oxide 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 3.0h， 以94%的产率得到dehydrocoelenterazine mono-methyl ether
  参考文献：
  名称：

  Synthesis of 13C-Dehydrocoelenterazine and NMR Studies on the Bioluminescence of a Symplectoteuthis Model

  摘要：

  The bioluminescence of luminous squid (Symplectoteuthis oualaniensis) is presumed to be initiated by the addition of the sulfhydryl residue of a photoprotein to dehydrocoelenterazine (DCL). To clarify this step, a novel synthetic route was established to label DCL with C-13. Dithiothreitol (DTT) and glutathione (GSH) were used as photoprotein models. The addition of DTT and GSH to C-13-labeled DCL gave luminous chromophores. Its structures were confirmed by NMR and MS spectrometry. The DTT adduct emitted light under alkaline condition to produce an oxidized compound. Thus we succeeded in modeling the bioluminescence of a photoprotein with DTT. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00163-0
• 作为产物：
  描述：

  4-甲氧基苯乙酰氯 在 盐酸 、 次氯酸叔丁酯 、 三甲基硅烷化重氮甲烷 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 、 水 、 乙腈 为溶剂， 反应 33.0h， 生成 2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one
  参考文献：
  名称：

  Coelenterazine analogs and manufacturing method thereof

  摘要：

  有一种需要具有与已知螺旋藻素类似物不同的发光特性的螺旋藻素类似物。本发明提供了一种由通式（1）表示的化合物。

  公开号：

  US08546568B2

文献信息

• COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF
  申请人：Inouye Satoshi

  公开号：US20120035070A1

  公开（公告）日：2012-02-09

  There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).

  需要一种表现出与已知的共生菌素类似的发光特性的共生菌素类似物。本发明提供了由一般式（1）表示的化合物。
• Compositions, methods and kits pertaining to luminescent compounds
  申请人：PROMEGA CORPORATION

  公开号：EP1894933B1

  公开（公告）日：2013-07-03
• Chemiluminescent methods and reagents for analyte detection
  申请人：Wang Tianxin

  公开号：US20110097753A1

  公开（公告）日：2011-04-28

  The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.
• CHEMILUMINESCENT METHODS AND REAGENTS FOR ANALYTE DETECTION
  申请人：Wang Tianxin

  公开号：US20160362388A1

  公开（公告）日：2016-12-15

  The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current invention relates to use chemiluminescent enzyme coupled with analyte binding molecules to detect specific analyte molecules in a homogenous phase.
• US8546568B2
  申请人：——

  公开号：US8546568B2

  公开（公告）日：2013-10-01