tert-butyl 4-(2-chloro-4-(methoxycarbonyl) phenoxy)piperidine-1-carboxylate | 947513-08-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl 4-(2-chloro-4-(methoxycarbonyl) phenoxy)piperidine-1-carboxylate
• 英文别名: Tert-butyl 4-(2-chloro-4-methoxycarbonylphenoxy)piperidine-1-carboxylate
• CAS: 947513-08-8
• 化学式: C₁₈H₂₄ClNO₅
• 分子量: 369.845
• InChiKey: DUGRGNUGYRLUBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(2-chloro-4-(methoxycarbonyl) phenoxy)piperidine-1-carboxylate 在 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 以92%的产率得到3-chloro-4-(piperidin-4-yloxy)benzoic acid methyl ester
  参考文献：
  名称：

  WO2007/98086

  摘要：

  公开号：
• 作为产物：
  描述：

  3-氯-4-羟基苯甲酸甲酯 、 N-Boc-4-羟基哌啶 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以88%的产率得到tert-butyl 4-(2-chloro-4-(methoxycarbonyl) phenoxy)piperidine-1-carboxylate
  参考文献：
  名称：

  WO2007/98086

  摘要：

  公开号：

文献信息

• Hydroxypiperidine Derivatives and Uses Thereof
  申请人：Ohler Norman E.

  公开号：US20090036429A1

  公开（公告）日：2009-02-05

  Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
• Hydroxypiperidine derivatives and uses thereof
  申请人：Ohler Norman E.

  公开号：US20110178066A1

  公开（公告）日：2011-07-21

  Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
• [EN] HYDROXYPIPERIDINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'HYDROXYPIPÉRIDINE ET LEURS UTILISATIONS
  申请人：AVALON PHARMACEUTICALS

  公开号：WO2007098086A2

  公开（公告）日：2007-08-30

  [EN] Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
  [FR] L'invention concerne des substances chimiques telles que des dérivés de fragments hydroxypipéridine et des structures à noyau hétérocyclique similaires, y compris leurs sels, qui agissent comme des agents anticancéreux et antitumoraux, notamment lorsque ces agents modulent l'activité d'enzymes et de polypeptides structurels présents dans des cellules, par exemple des cellules cancéreuses, ou lorsque ces agents modulent les niveaux d'expression génique dans des systèmes cellulaires, y compris des cellules cancéreuses, ainsi que des procédés de préparation de ces agents, des compositions pharmaceutiques contenant ces agents en tant que principes actifs, et des procédés pour les utiliser comme agents thérapeutiques.
• WO2007/98086
  申请人：——

  公开号：——

  公开（公告）日：——