10-[2-(N-Boc-4-piperidyl)ethyl]-2-trifluoromethylphenothiazine | 1009797-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 10-[2-(N-Boc-4-piperidyl)ethyl]-2-trifluoromethylphenothiazine
• 英文别名: Tert-butyl 4-[2-[2-(trifluoromethyl)phenothiazin-10-yl]ethyl]piperidine-1-carboxylate
• CAS: 1009797-58-3
• 化学式: C₂₅H₂₉F₃N₂O₂S
• 分子量: 478.579
• InChiKey: KGZQZJYIYQJXFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  10-[2-(N-Boc-4-piperidyl)ethyl]-2-trifluoromethylphenothiazine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以69%的产率得到ICI-1007
  参考文献：
  名称：

  WO2008/27521

  摘要：

  公开号：
• 作为产物：
  描述：

  2-三氟甲基吩噻嗪 、 4-(2-溴乙基)哌啶-1-羧酸叔丁酯 在 sodium hydride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 12.0h， 以65%的产率得到10-[2-(N-Boc-4-piperidyl)ethyl]-2-trifluoromethylphenothiazine
  参考文献：
  名称：

  WO2008/27521

  摘要：

  公开号：

文献信息

• Novel Compositions and Methods of Treating Diseases Using the Same
  申请人：Roth Stephen

  公开号：US20120035161A1

  公开（公告）日：2012-02-09

  The invention includes compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, treating diseases associated with activated lymphocytes, or treating PAH.

  本发明涉及抑制活化淋巴细胞增殖和诱导凋亡的组合物和方法，用于治疗与活化淋巴细胞相关的疾病或治疗PAH。
• NOVEL COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES RELATED TO ACTIVATED LYMPHOCYTES
  申请人：Immune Control, Inc.

  公开号：EP2061788A1

  公开（公告）日：2009-05-27
• Novel methods for treatment of diseases related to activated lymphocytes
  申请人：Roth Stephen

  公开号：US20080125415A1

  公开（公告）日：2008-05-29

  The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
• Novel compositions for treatment of diseases related to activated lymphocytes
  申请人：Roth Stephen

  公开号：US20080132697A1

  公开（公告）日：2008-06-05

  The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
• US7923445B2
  申请人：——

  公开号：US7923445B2

  公开（公告）日：2011-04-12