(2S,4R)-4-(4-methoxybenzylsulfanyl)-1-(naphthalene-2-sulfonyl)pyrrolidine-2-carboxylic acid N'-methyl-N'-(4-methylphenylsulfonyl)hydrazide | 844476-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2S,4R)-4-(4-methoxybenzylsulfanyl)-1-(naphthalene-2-sulfonyl)pyrrolidine-2-carboxylic acid N'-methyl-N'-(4-methylphenylsulfonyl)hydrazide
• 英文别名: (2S,4R)-4-[(4-methoxyphenyl)methylsulfanyl]-N'-methyl-N'-(4-methylphenyl)sulfonyl-1-naphthalen-2-ylsulfonylpyrrolidine-2-carbohydrazide
• CAS: 844476-78-4
• 化学式: C₃₁H₃₃N₃O₆S₃
• 分子量: 639.818
• InChiKey: WPBPYGYXFJYSDC-OFSOJUDTSA-N

物化性质

• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  155
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (2S,4R)-4-(4-methoxybenzylsulfanyl)-1-(naphthalene-2-sulfonyl)pyrrolidine-2-carboxylic acid N'-methyl-N'-(4-methylphenylsulfonyl)hydrazide 在 三乙基硅烷 、 三氟乙酸 作用下， 反应 1.5h， 以53%的产率得到(2S,4R)-4-Mercapto-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid N'-methyl-N'-(4-methyl-benzenesulfonyl)-hydrazide
  参考文献：
  名称：

  Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

  摘要：

  Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the endothelin-converting enzymes 1(a-d) (ECE-1(a-d); EC 3.4.24.71) represents another approach to block the ET-1 effect in cancer. To evaluate this potential, we synthesized and characterized a series of low nanomolar nonpeptidic thiol-containing ECE-1 inhibitors, and evaluated their effect, as well as the effect of inhibitors for the related metalloproteases neprilysin (NEP; EC 3.4.24.11) and angiotensin-converting enzyme (ACE: EC 3.4.15.1). on human glioblastoma cell growth. Only ECE-1 inhibitors inhibited DNA synthesis by human glioblastoma cells. Exogenous addition of ET-1 or bigET-1 to glioblastoma cells did not counterbalance the growth inhibition elicited by ECE-1 inhibitors, suggesting that ECE-1 inhibitors block the proliferation of human glioblastoma cells most likely via a mechanism not involving extracellular production of ET-1. This class of molecules may thus represent novel therapeutic agents for the potential treatment of human cancer.

  DOI：

  10.1021/jm040857x
• 作为产物：
  描述：

  反式-4-羟基-L-脯氨酸甲酯盐酸盐 在 羟吡啶酮 、 4-二甲氨基吡啶 、 lithium hydroxide 、 potassium tert-butylate 、 三乙胺 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 、 三苯基膦 、 六甲基二硅氮烷 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 26.33h， 生成 (2S,4R)-4-(4-methoxybenzylsulfanyl)-1-(naphthalene-2-sulfonyl)pyrrolidine-2-carboxylic acid N'-methyl-N'-(4-methylphenylsulfonyl)hydrazide
  参考文献：
  名称：

  Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

  摘要：

  Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the endothelin-converting enzymes 1(a-d) (ECE-1(a-d); EC 3.4.24.71) represents another approach to block the ET-1 effect in cancer. To evaluate this potential, we synthesized and characterized a series of low nanomolar nonpeptidic thiol-containing ECE-1 inhibitors, and evaluated their effect, as well as the effect of inhibitors for the related metalloproteases neprilysin (NEP; EC 3.4.24.11) and angiotensin-converting enzyme (ACE: EC 3.4.15.1). on human glioblastoma cell growth. Only ECE-1 inhibitors inhibited DNA synthesis by human glioblastoma cells. Exogenous addition of ET-1 or bigET-1 to glioblastoma cells did not counterbalance the growth inhibition elicited by ECE-1 inhibitors, suggesting that ECE-1 inhibitors block the proliferation of human glioblastoma cells most likely via a mechanism not involving extracellular production of ET-1. This class of molecules may thus represent novel therapeutic agents for the potential treatment of human cancer.

  DOI：

  10.1021/jm040857x