2,6-di(thiazol-2-yl)pyridine | 128141-02-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-di(thiazol-2-yl)pyridine
• 英文别名: 2,6-Bis(thiazol-2-yl) pyridine；2-[6-(1,3-thiazol-2-yl)pyridin-2-yl]-1,3-thiazole
• CAS: 128141-02-6
• 化学式: C₁₁H₇N₃S₂
• 分子量: 245.329
• InChiKey: CZRQCLSOQKQYFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ferrous perchlorate 、 2,6-di(thiazol-2-yl)pyridine 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Baker, Anthony T.; Singh, Pratibha; Vignevich, Valentina, Australian Journal of Chemistry, 1991, vol. 44, # 8, p. 1041 - 1048

  摘要：

  DOI：
• 作为产物：
  描述：

  吡啶-2,6-二甲酰胺 在 吡啶 、 diphosphorus pentasulfide 作用下， 反应 12.0h， 生成 2,6-di(thiazol-2-yl)pyridine
  参考文献：
  名称：

  Baker, Anthony T.; Singh, Pratibha; Vignevich, Valentina, Australian Journal of Chemistry, 1991, vol. 44, # 8, p. 1041 - 1048

  摘要：

  DOI：

文献信息

• Synthesis, characterization and biological evaluation of ruthenium(II) complexes [Ru(dtzp)(dppz)Cl] + and [Ru(dtzp)(dppz)CH 3 CN] 2+ for photodynamic therapy
  作者：Hui-juan Yu、Jiang-ping Liu、Zhi-feng Hao、Jun He、Ming Sun、Sheng Hu、Lin Yu、Hui Chao

  DOI：10.1016/j.dyepig.2016.08.059

  日期：2017.1

  Two new Ru(II) complexes [Ru(dtzp)(dppz)Cl]+ 1 and [Ru(dtzp)(dppz)CH3CN]2+ 2 (dtzp = 2,6-di(thiazo1-2-yl)pyridine; dppz = dipyrido[3,2-a:2′,3′-c]phenazine) have been synthesized and evaluated as photodynamic anticancer agents. The results of the spectra titration, thermal denaturation and electrophoresis experiments suggest that both complexes could intercalatively bind to DNA and photocleave DNA efficiently

  两个新的Ru（II）络合物[Ru（dtzp）（dppz）Cl] + 1和[Ru（dtzp）（dppz）CH 3 CN] 2+ 2（dtzp = 2,6-di（thiazo1-2-yl）吡啶； dppz =二吡啶基[3,2- a：2'，3'- c ]吩嗪）已经合成并评估为光动力抗癌剂。光谱滴定，热变性和电泳实验的结果表明，两种复合物都可以通过ROS的产生和光诱导的电子转移而嵌入到DNA上并有效地裂解DNA。在可见光（470 nm）下孵育时，复合物1和2在2D癌细胞单层和3D MCTS癌症模型中均对Hela细胞产生巨大的光细胞毒性，复合物1观察到更大的光细胞毒性，这可能与其在470 nm处更大的细胞吸收效率和更强的吸收有关。流式细胞仪分析和免疫荧光分析显示，复合物1通过G2M相周期停滞和细胞凋亡抑制Hela细胞增殖，并可能对染色质DNA产生很大的光损伤。复合物1可能是用于治疗宫颈癌的重要PDT候选药物。
• Polycyclic Pyridines as Potassium Ion Channel Modulators
  申请人：Wang Xiaodong

  公开号：US20080108600A1

  公开（公告）日：2008-05-08

  The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环吡啶，可用作钾离子通道的调节剂。本发明的调节剂在治疗和诊断方法中均有用途。
• Convenient Synthesis of Various Terheterocyclic Compounds by Pd(0)-Catalyzed Coupling Reactions
  作者：Salo Gronowitz、Dan Peters

  DOI：10.3987/com-89-s90

  日期：——
• Baker, Anthony T.; Craig, Donald C.; Singh, Pratibha, Australian Journal of Chemistry, 1991, vol. 44, p. 1659 - 1668
  作者：Baker, Anthony T.、Craig, Donald C.、Singh, Pratibha

  DOI：——

  日期：——
• Synthesis, crystal structure, DNA interaction and anticancer activity of tridentate copper(II) complexes
  作者：Guan-Ying Li、Ke-Jie Du、Jin-Quan Wang、Jie-Wen Liang、Jun-Feng Kou、Xiao-Juan Hou、Liang-Nian Ji、Hui Chao

  DOI：10.1016/j.jinorgbio.2012.09.019

  日期：2013.2

  Three new tridentate copper(II) complexes [Cu(dthp)Cl-2] (1) (dthp = 2,6-di(thiazol-2-yl)pyridine), [Cu(dmtp)Cl-2] (2) (dmtp = 2,6-di(5-methyl-4H-1,2,4-triazol-3-yl)pyridine) and [Cu(dtp)Cl-2] (3) (dtp = 2,6-di(4H-1,2,4-triazol-3-yl)pyridine) have been synthesized and characterized. Crystal structure of complex 1 shows that the complex existed as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. Ethidium bromide displacement assay, viscosity measurements, circular dichroism studies and cyclic voltammetric experiments suggested that these complexes bound to DNA via an intercalative mode. Three Cu(II) complexes were found to efficiently cleave DNA in the presence of sodium ascorbate, and singlet oxygen (O-1(2)) and hydrogen peroxide were proved to contribute to the DNA cleavage process. They exhibited anticancer activity against HeLa, Hep-G2 and BEL-7402 cell lines. Nuclear chromatin cleavage has also been observed with AO/EB staining assay and the alkaline single-cell gel electrophoresis (comet assay). The results demonstrated that three Cu(II) complexes cause DNA damage that can induce the apoptosis of BEL-7402 cells. (C) 2012 Elsevier Inc. All rights reserved.