7-甲氧基-3-色满胺 | 119755-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 7-甲氧基-3-色满胺
• 英文名称: 7-methoxy-3-amino-3,4-dihydro-2H-1-benzopyran
• 英文别名: 3-amino-7-methoxychroman；7-Methoxychroman-3-amine；7-methoxy-3,4-dihydro-2H-chromen-3-amine
• CAS: 119755-64-5
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD09261196
• 分子量: 179.219
• InChiKey: JGIHXVOYCDUASG-UHFFFAOYSA-N

物化性质

• 沸点：
  298.5±40.0 °C(Predicted)
• 密度：
  1.128±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  7-甲氧基-3-色满胺 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 2-Dipropylaminomethyl-2,3-dihydro-benzofuran-6-ol
  参考文献：
  名称：

  N,N -Disubstituted Aminomethyl Benzofuran Derivatives: Synthesis and Preliminary Binding Evaluation

  摘要：

  A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT1A, 5-HT2A, 5-HT2C, 5-H-3, D-2, and D-3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2h-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT1A sites with nanomolar affinity (IC50 = 1.5 nM) and high selectivity over 5-HT2A, 5-HT2C, 5-HT3, D-2, and D-3 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00239-9
• 作为产物：
  描述：

  7-甲氧基-3-硝基-2H-苯并吡喃 在 sodium tetrahydroborate 、 silica gel 、 镍 、 一水合肼 作用下， 以 乙醇 、 氯仿 、 异丙醇 为溶剂， 反应 2.75h， 生成 7-甲氧基-3-色满胺
  参考文献：
  名称：

  N,N -Disubstituted Aminomethyl Benzofuran Derivatives: Synthesis and Preliminary Binding Evaluation

  摘要：

  A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT1A, 5-HT2A, 5-HT2C, 5-H-3, D-2, and D-3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2h-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT1A sites with nanomolar affinity (IC50 = 1.5 nM) and high selectivity over 5-HT2A, 5-HT2C, 5-HT3, D-2, and D-3 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00239-9

文献信息

• ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF
  申请人：Bayburt Erol K.

  公开号：US20080153871A1

  公开（公告）日：2008-06-26

  The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar 1 , L 1 , R 1 , R 2 , R 3 , R 4 , R 5 , Y 1 , Y 2 , and Y 3 , are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

  本申请涉及的化合物是TRPV1拮抗剂，其化学式为（I），其中变量Ar1，L1，R1，R2，R3，R4，R5，Y1，Y2和Y3如描述中所定义，对于治疗由辣椒素受体活性引起或加剧的疾病是有用的。
• 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation,
  申请人：Hoechst Aktiengesellschaft

  公开号：US05849755A1

  公开（公告）日：1998-12-15

  3-amidochromanylsulfonyl(thio)ureas of the formula (I): ##STR1## which are valuable pharmaceutically active compounds for the treatment of disturbances of the cardiovascular system, in particular for the treatment of arrhythmias, for preventing sudden cardiac death or for influencing a reduced contractility of the heart, and processes for their preparation, their use and pharmaceutical preparations comprising them.

  化学式（I）的3-氨基色基磺酰基（硫）脲： ##STR1## 是用于治疗心血管系统紊乱，特别是用于治疗心律失常，预防猝死或影响心脏收缩力降低的有价值的药用化合物，以及它们的制备过程、用途和包含它们的药物制剂。
• 3-aminochroman compounds
  申请人：Adir et Compagnie

  公开号：US05273994A1

  公开（公告）日：1993-12-28

  The invention relates to the derivatives of general formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom, R.sub.1 represents a hydrogen atom or an alkyl group, R.sub.2 represents a hydrogen atom or an alkyl group, 1.ltoreq.n.ltoreq.6, R.sub.3 represents a nitrile group, an optionally substituted amino group or any one of the groups described in the description, and medicinal products containing the same.

  本发明涉及一种通式(I)的衍生物：##STR1## 其中：Z代表氧原子或硫原子，R1代表氢原子或烷基，R2代表氢原子或烷基，1≤n≤6，R3代表腈基、可选取代的氨基或描述于说明书中的任一基团，以及含有这种衍生物的药物制剂。
• 3-aminochroan compounds
  申请人：Adir et Compagnie

  公开号：US05314907A1

  公开（公告）日：1994-05-24

  The invention relates to the derivatives of general formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom, R.sub.1 represents a hydrogen atom or an alkyl group, R.sub.2 represents a hydrogen atom or an alkyl group, 1.ltoreq.n.ltoreq.6, R.sub.3 represents a nitrile group, an optionally substituted amino group or any one of the groups described in the description and medicinal products containing the same.

  本发明涉及一般式（I）的衍生物：##STR1## 其中：Z代表氧原子或硫原子，R.sub.1代表氢原子或烷基，R.sub.2代表氢原子或烷基，1≤n≤6，R.sub.3代表腈基，可选地取代的氨基或描述中的任何一种基团，以及含有这些衍生物的药物制品。
• Alkoxy-3-[(Toluenesulfonylaminoalkyl)amino] chroman compounds
  申请人：Adir Et Compagnie

  公开号：US05346916A1

  公开（公告）日：1994-09-13

  The invention relates to compounds of the formula (I): ##STR1## in which: Z represents an oxygen atom or a sulfur atom, R.sub.1 represents a hydrogen atom or an alkyl group, R.sub.2 represents a hydrogen atom or an alkyl group, n is one to six, inclusive, R.sub.3 represents an amino group, substituted with phenylsulfonyl, and medicinal products containing the same.

  本发明涉及公式(I)的化合物：##STR1## 其中：Z代表氧原子或硫原子，R.sub.1代表氢原子或烷基，R.sub.2代表氢原子或烷基，n为1至6（包括1和6），R.sub.3代表取代苯磺酰氨基的氨基，以及含有这些化合物的药物产品。