1-(2-甲基-4H-呋喃并[3,2-b]吡咯-4-基)乙酮 | 132120-23-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡咯
• 中文名称: 1-(2-甲基-4H-呋喃并[3,2-b]吡咯-4-基)乙酮
• 英文名称: 2-methyl-4-acetylfuro<3,2-b>pyrrole
• 英文别名: 1-(2-Methyl-4H-furo[3,2-b]pyrrol-4-yl)ethanone；1-(2-methylfuro[3,2-b]pyrrol-4-yl)ethanone
• CAS: 132120-23-1
• 化学式: C₉H₉NO₂
• 分子量: 163.176
• InChiKey: XXWXHVUFDLMIBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  35.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-甲基-4H-呋喃并[3,2-b]吡咯-4-基)乙酮 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 以50%的产率得到2-methyl-4-acetylfuro<3,2-b>pyrrole
  参考文献：
  名称：

  Condensed O-, N-heterocycles by the transformation of azidoacrylates

  摘要：

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.

  DOI：

  10.1007/bf00812330
• 作为产物：
  描述：

  2-甲基-4H-呋喃并[3,2-b]吡咯-5-羧酸乙酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 1-(2-甲基-4H-呋喃并[3,2-b]吡咯-4-基)乙酮
  参考文献：
  名称：

  Condensed O-, N-heterocycles by the transformation of azidoacrylates

  摘要：

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.

  DOI：

  10.1007/bf00812330

文献信息

• Condensed O-, N-heterocycles by the transformation of azidoacrylates
  作者：Alzbeta Krutosikova、Miloslava Dandarova、Jana Chylova、Daniel Vegh

  DOI：10.1007/bf00812330

  日期：——

  A number of furo[3,2-c]pyridines (4 a-4 d) and benzo[b]derivative (4e), as well as pyrrolo[2',3'-4,5]furo[3,2-c]pyridine (8) were prepared by reaction of the corresponding iminophosphoranes, available from ethyl azidoheteroacrylates and triphenylphosphine, with phenyl isocyanate. The appropriate azidoheteroacrylates were used for the preparation of some substituted furo[3,2-b:4,5-b]dipyrroles (6). The reactions of the prepared compounds are described.

表征谱图