2-[(2-oxo-1H-benzo[cd]indol-6-yl)sulfonylamino]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(2-oxo-1H-benzo[cd]indol-6-yl)sulfonylamino]benzoic acid
• 化学式: C₁₈H₁₂N₂O₅S
• 分子量: 368.37
• InChiKey: TYNXIZLQXIBWGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-羟基-1,8-萘二甲酰亚胺 在 吡啶 、 盐酸 、 palladium 10% on activated carbon 、 氢气 、 硝酸 、 溶剂黄146 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 26.0h， 生成 2-[(2-oxo-1H-benzo[cd]indol-6-yl)sulfonylamino]benzoic acid
  参考文献：
  名称：

  Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors

  摘要：

  New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1-sulfonamide inhibited FGFR1 with IC50 of 2 mu M. In our preliminary studies, N-phenylnaphthostyril-1-sulfonamides demonstrated selectivity of FGFR1 inhibition and antiproliferative activity on cancer cell line. N-phenylnaphthostyril-1-sulfonamides have a good potential for further development as anticancer agents.

  DOI：

  10.3109/14756366.2014.895718

文献信息

• Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors
  作者：Andrii Anatoliyovych Gryshchenko、Kostiantyn Vasyliovych Levchenko、Volodymyr Grygorovich Bdzhola、Tatiana Panasivna Ruban、Lyubov Leonidovna Lukash、Sergiy Mikolayovych Yarmoluk

  DOI：10.3109/14756366.2014.895718

  日期：2015.1.2

  New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1-sulfonamide inhibited FGFR1 with IC50 of 2 mu M. In our preliminary studies, N-phenylnaphthostyril-1-sulfonamides demonstrated selectivity of FGFR1 inhibition and antiproliferative activity on cancer cell line. N-phenylnaphthostyril-1-sulfonamides have a good potential for further development as anticancer agents.