N-Benzyl-3,5-dimethoxybenzylamin | 30856-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyl-3,5-dimethoxybenzylamin
• 英文别名: N-[(3,5-dimethoxyphenyl)methyl]-1-phenylmethanamine
• CAS: 30856-51-0
• 化学式: C₁₆H₁₉NO₂
• mdl: MFCD12551577
• 分子量: 257.332
• InChiKey: SCORGFTVFPJFDN-UHFFFAOYSA-N

物化性质

• 沸点：
  387.3±32.0 °C(Predicted)
• 密度：
  1.073±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 N-Benzyl-3,5-dimethoxybenzylamin 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  A Lewis-Acid Catalyzed Synthesis of Substituted Oxindole Derivatives

  摘要：

  Lewis acid-catalyzed cyclization of various 2-(N-arylcarbamoyl)-methylenemalonates to give nitrogen-containing benzo-annelated heterocycles was investigated in terms of selectivity. Reaction of substrates with various alkyl groups on nitrogen proceeded to give oxindole derivatives. Cyclization reaction of diester-amides of MeO and halooen-substituted anilines in the presence of catalytic Lewis acid (ZnCl2, SnCl4, AlCl3, Zn(OTf)(2), Sc(OTf)(3), etc.) gave oxindoles in high yields. Interesting regioselectivity was observed for meta- halogen substrates. Dimethoxyisoquinoline analogs were also obtained by this reaction using a catalytic Lewis acid.

  DOI：

  10.3987/com-05-s(t)25
• 作为产物：
  描述：

  3,5-二甲氧基苄胺 、 苯甲醇 在 potassium tert-butylate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以79%的产率得到N-Benzyl-3,5-dimethoxybenzylamin
  参考文献：
  名称：

  用于胺和氨与醇的一般和选择性N-烷基化的可重复使用的Co纳米颗粒

  摘要：

  报道了一种通用的钴催化胺与醇的N-烷基化反应，利用氢方法制备不同种类的胺。这种转化的最佳催化剂是通过热解特定的模板材料来制备的，该模板材料是通过混合钴盐、氮配体和胶态二氧化硅原位生成的，然后去除二氧化硅。应用这种新型Co纳米粒子基材料，>100伯胺、仲胺和叔胺（包括N-甲胺）和选定的药物分子可以从廉价且容易获得的醇和胺或氨开始方便地制备。

  DOI：

  10.1039/d1sc05913k

文献信息

• US5621103A
  申请人：——

  公开号：US5621103A

  公开（公告）日：1997-04-15
• Reusable Co-nanoparticles for general and selective <i>N</i>-alkylation of amines and ammonia with alcohols
  作者：Zhuang Ma、Bei Zhou、Xinmin Li、Ravishankar G. Kadam、Manoj B. Gawande、Martin Petr、Radek Zbořil、Matthias Beller、Rajenahally V. Jagadeesh

  DOI：10.1039/d1sc05913k

  日期：——

  A general cobalt-catalyzed N-alkylation of amines with alcohols by borrowing hydrogen methodology to prepare different kinds of amines is reported. The optimal catalyst for this transformation is prepared by pyrolysis of a specific templated material, which is generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica, and subsequent removal of silica. Applying this novel Co-nanoparticle-based

  报道了一种通用的钴催化胺与醇的N-烷基化反应，利用氢方法制备不同种类的胺。这种转化的最佳催化剂是通过热解特定的模板材料来制备的，该模板材料是通过混合钴盐、氮配体和胶态二氧化硅原位生成的，然后去除二氧化硅。应用这种新型Co纳米粒子基材料，>100伯胺、仲胺和叔胺（包括N-甲胺）和选定的药物分子可以从廉价且容易获得的醇和胺或氨开始方便地制备。
• A Lewis-Acid Catalyzed Synthesis of Substituted Oxindole Derivatives
  作者：Shoko Yamazaki、Machiko Yamamoto、Satoshi Morikawa

  DOI：10.3987/com-05-s(t)25

  日期：——

  Lewis acid-catalyzed cyclization of various 2-(N-arylcarbamoyl)-methylenemalonates to give nitrogen-containing benzo-annelated heterocycles was investigated in terms of selectivity. Reaction of substrates with various alkyl groups on nitrogen proceeded to give oxindole derivatives. Cyclization reaction of diester-amides of MeO and halooen-substituted anilines in the presence of catalytic Lewis acid (ZnCl2, SnCl4, AlCl3, Zn(OTf)(2), Sc(OTf)(3), etc.) gave oxindoles in high yields. Interesting regioselectivity was observed for meta- halogen substrates. Dimethoxyisoquinoline analogs were also obtained by this reaction using a catalytic Lewis acid.